ID RNC_BIFLO Reviewed; 242 AA.
AC Q8G7H1;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 2.
DT 01-MAY-2013, entry version 58.
DE RecName: Full=Ribonuclease 3;
DE EC=3.1.26.3;
DE AltName: Full=Ribonuclease III;
DE Short=RNase III;
GN Name=rnc; OrderedLocusNames=BL0295;
OS Bifidobacterium longum (strain NCC 2705).
OC Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=206672;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCC 2705;
RX PubMed=12381787; DOI=10.1073/pnas.212527599;
RA Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B.,
RA Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M.,
RA Pridmore R.D., Arigoni F.;
RT "The genome sequence of Bifidobacterium longum reflects its adaptation
RT to the human gastrointestinal tract.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC -!- FUNCTION: Digests double-stranded RNA. Involved in the processing
CC of primary rRNA transcript to yield the immediate precursors to
CC the large and small rRNAs (23S and 16S). Also processes some
CC mRNAs, and tRNAs when they are encoded in the rRNA operon (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC phosphomonoester.
CC -!- COFACTOR: Mg(2+) (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
CC -!- SIMILARITY: Contains 1 RNase III domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN24135.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
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DR EMBL; AE014295; AAN24135.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_695499.1; NC_004307.2.
DR ProteinModelPortal; Q8G7H1; -.
DR STRING; 206672.BL0295; -.
DR EnsemblBacteria; AAN24135; AAN24135; BL0295.
DR GeneID; 1022381; -.
DR KEGG; blo:BL0295; -.
DR PATRIC; 21119145; VBIBifLon107831_1032.
DR eggNOG; COG0571; -.
DR HOGENOM; HOG000246808; -.
DR KO; K03685; -.
DR OMA; PDHARTF; -.
DR ProtClustDB; PRK00102; -.
DR BioCyc; BLON206672:GI1E-937-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:HAMAP.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:HAMAP.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:HAMAP.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1520.10; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR HAMAP; MF_00104; RNase_III; 1; -.
DR InterPro; IPR001159; Ds-RNA-bd.
DR InterPro; IPR014720; dsRNA-bd-like_dom.
DR InterPro; IPR011907; RNase_III.
DR InterPro; IPR000999; RNase_III_dom.
DR PANTHER; PTHR11207; PTHR11207; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF00636; Ribonuclease_3; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00535; RIBOc; 1.
DR SUPFAM; SSF69065; RNase_III; 1.
DR TIGRFAMs; TIGR02191; RNaseIII; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW Metal-binding; mRNA processing; Nuclease; Reference proteome;
KW RNA-binding; rRNA processing; rRNA-binding; tRNA processing.
FT CHAIN 1 242 Ribonuclease 3.
FT /FTId=PRO_0000228502.
FT DOMAIN 12 139 RNase III.
FT DOMAIN 165 236 DRBM.
FT ACT_SITE 55 55 Potential.
FT ACT_SITE 128 128 By similarity.
FT METAL 51 51 Magnesium (By similarity).
FT METAL 125 125 Magnesium (By similarity).
FT METAL 128 128 Magnesium (By similarity).
SQ SEQUENCE 242 AA; 26080 MW; AA294ECE97373D1C CRC64;
MSNETPQQPT PANELLEALG TTLSPDLLVQ ALTHRSFSHE HPGVANYERL EFLGDAVLEL
VSTETLFTIH PDMTEGQLAK MRAKAVSEDA LSAIAKTKLK VGPYILLGHG EAEQGGAEKN
SILCDIVESL IGATFLEHGI DEARKVIHRL IDDTLAEVAT EGPALDWKTS LTVKAHGLGK
EEPVYHMEVS GPEYAQIFTA RVSLGENGDI IGIGKGSSKR KAQLAAAEAG WKSLDSFKTR
TK
//
