ID Q8GGS4_STRAZ Unreviewed; 774 AA.
AC Q8GGS4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Putative transcriptional regulator {ECO:0000313|EMBL:AAN85491.1};
OS Streptomyces atroolivaceus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=66869 {ECO:0000313|EMBL:AAN85491.1};
RN [1] {ECO:0000313|EMBL:AAN85491.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12446651; DOI=10.1128/JB.184.24.7013-7024.2002;
RA Cheng Y.Q., Tang G.L., Shen B.;
RT "Identification and localization of the gene cluster encoding biosynthesis
RT of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-
RT 140.";
RL J. Bacteriol. 184:7013-7024(2002).
RN [2] {ECO:0000313|EMBL:AAN85491.1}
RP NUCLEOTIDE SEQUENCE.
RA Cheng Y.-Q., Tang G.-L., Shen B.;
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAN85491.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12598647; DOI=10.1073/pnas.0537286100;
RA Cheng Y.Q., Tang G.L., Shen B.;
RT "Type I polyketide synthase requiring a discrete acyltransferase for
RT polyketide biosynthesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:3149-3154(2003).
RN [4] {ECO:0000313|EMBL:AAN85491.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15112993; DOI=10.1016/S1074-5521(03)00286-2;
RA Tang G.L., Cheng Y.Q., Shen B.;
RT "Leinamycin biosynthesis revealing unprecedented architectural complexity
RT for a hybrid polyketide synthase and nonribosomal peptide synthetase.";
RL Chem. Biol. 11:33-45(2004).
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DR EMBL; AF484556; AAN85491.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8GGS4; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 701..766
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT REGION 526..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 82386 MW; CCAB1D331C9EE1ED CRC64;
MEFSSRSSTS STTGAPLLSV RSAGEIVPVL CPDGFEVGGG PRVVEVVADR WAGKSTVLDG
LSAALAGRGW TVAAGAASPA RSRAPFGVFV EALEELVEHL DPDRLGGRGR DHAAQLAALF
PALSPDAPRD TSVDTYRICR AMRALLEMLA ADGPLLLALD DVHWMDADSL ELLGQLLEQP
VAGPVVIAVA HRGRPGDRVL NGLLARCASR GGCLRVRPAP LTEQEAIALL PDDLSRVHCE
TLLVESGGSP GLLRAFATLR QVPGLTGAWT PPLPADLLAD VLRDFRALSA EGWQVVRAAA
VLHEPYAADD LKEIAHVDDA ALWRALDELI HEELLRPDEL PWQLRFANPL LRVAAYQSAG
RGWLLGAHAQ AARILARPGY PSAHMARHLE RGAALRDESG ARVLWDAAAR LLWQDPSQSV
SWIRAALASR AGGDLEPRDR LLFGKALALA GRLTESLATL GPFGQGGVEA GLRVERVRWR
AHAHRLLGHT DRAQDELESL LAELEPGEEG LRDVVRHALI ELALHGRRPV PPPPGGSEPG
MPQGATGALR GRLLAQLAVA ACRGGEQERA EQRALTARQL LDAAPDGEVA EQLEGLYWLA
TAEAALGRPS AACGHYERGL RIAETRRLID HVPLFAMALS ALQLHTGDGA GAARHAACAE
TVAAATESEH LRERALRLRR ETASGAGVAV LPGQRQPADA AAVALEGLSR RESEVALLVS
GGRTNQQIAR VLELSHKTVE TYLGRIFQKL QVQSRAEVAA MVGRSDRLGV AAGS
//