ID   Q8GGS4_STRAZ            Unreviewed;       774 AA.
AC   Q8GGS4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   SubName: Full=Putative transcriptional regulator {ECO:0000313|EMBL:AAN85491.1};
OS   Streptomyces atroolivaceus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=66869 {ECO:0000313|EMBL:AAN85491.1};
RN   [1] {ECO:0000313|EMBL:AAN85491.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12446651; DOI=10.1128/JB.184.24.7013-7024.2002;
RA   Cheng Y.Q., Tang G.L., Shen B.;
RT   "Identification and localization of the gene cluster encoding biosynthesis
RT   of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-
RT   140.";
RL   J. Bacteriol. 184:7013-7024(2002).
RN   [2] {ECO:0000313|EMBL:AAN85491.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Cheng Y.-Q., Tang G.-L., Shen B.;
RL   Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAN85491.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12598647; DOI=10.1073/pnas.0537286100;
RA   Cheng Y.Q., Tang G.L., Shen B.;
RT   "Type I polyketide synthase requiring a discrete acyltransferase for
RT   polyketide biosynthesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:3149-3154(2003).
RN   [4] {ECO:0000313|EMBL:AAN85491.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15112993; DOI=10.1016/S1074-5521(03)00286-2;
RA   Tang G.L., Cheng Y.Q., Shen B.;
RT   "Leinamycin biosynthesis revealing unprecedented architectural complexity
RT   for a hybrid polyketide synthase and nonribosomal peptide synthetase.";
RL   Chem. Biol. 11:33-45(2004).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF484556; AAN85491.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8GGS4; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          701..766
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
FT   REGION          526..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  82386 MW;  CCAB1D331C9EE1ED CRC64;
     MEFSSRSSTS STTGAPLLSV RSAGEIVPVL CPDGFEVGGG PRVVEVVADR WAGKSTVLDG
     LSAALAGRGW TVAAGAASPA RSRAPFGVFV EALEELVEHL DPDRLGGRGR DHAAQLAALF
     PALSPDAPRD TSVDTYRICR AMRALLEMLA ADGPLLLALD DVHWMDADSL ELLGQLLEQP
     VAGPVVIAVA HRGRPGDRVL NGLLARCASR GGCLRVRPAP LTEQEAIALL PDDLSRVHCE
     TLLVESGGSP GLLRAFATLR QVPGLTGAWT PPLPADLLAD VLRDFRALSA EGWQVVRAAA
     VLHEPYAADD LKEIAHVDDA ALWRALDELI HEELLRPDEL PWQLRFANPL LRVAAYQSAG
     RGWLLGAHAQ AARILARPGY PSAHMARHLE RGAALRDESG ARVLWDAAAR LLWQDPSQSV
     SWIRAALASR AGGDLEPRDR LLFGKALALA GRLTESLATL GPFGQGGVEA GLRVERVRWR
     AHAHRLLGHT DRAQDELESL LAELEPGEEG LRDVVRHALI ELALHGRRPV PPPPGGSEPG
     MPQGATGALR GRLLAQLAVA ACRGGEQERA EQRALTARQL LDAAPDGEVA EQLEGLYWLA
     TAEAALGRPS AACGHYERGL RIAETRRLID HVPLFAMALS ALQLHTGDGA GAARHAACAE
     TVAAATESEH LRERALRLRR ETASGAGVAV LPGQRQPADA AAVALEGLSR RESEVALLVS
     GGRTNQQIAR VLELSHKTVE TYLGRIFQKL QVQSRAEVAA MVGRSDRLGV AAGS
//