ID Q8GI91_9NOCA Unreviewed; 418 AA.
AC Q8GI91;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:BAC54059.1};
OS Nocardia salmonicida.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=53431 {ECO:0000313|EMBL:BAC54059.1};
RN [1] {ECO:0000313|EMBL:BAC54059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFO13393 {ECO:0000313|EMBL:BAC54059.1};
RA Kasai H., Watanabe K., Harayama S.;
RT "Phylogenetic structure of suborder Corynebacterineae deduced from the gyrB
RT sequences.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; AB075568; BAC54059.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8GI91; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 342..418
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAC54059.1"
FT NON_TER 418
FT /evidence="ECO:0000313|EMBL:BAC54059.1"
SQ SEQUENCE 418 AA; 45691 MW; ADA1A4D1A924E378 CRC64;
SDSYAVSGGL HGVGISVVNA LSTKVEVEID VDGYHWTQTY KDAKPGKLAQ GEATKATGTT
VRFWADPDIF ETTTYNFETV ARRLQEMAFL NKGLTIKLTD ERVAVGDVID EVVSETAEAP
KDAEVVAAEA AEHKVKTRTY HYPGGLVDFV RHINRTKSAI HNSVVGYTVK GTGHELEVAM
QWNSGYSESV HTFANTINTH EGGTHEEGFR AALTTVVNKY AKEKKLLKEK DGNLTGDDIR
EGLAAIVSVK VGEPQFEGQT KTKLGNTEVK SFVQRACNEH LQHWFEANPA DAKTIVQKAV
SSAQARMAAR KARELVRRKS ATDLGGLPGK LADCRSKDPG KCEIYIVEGD SAGGSAKSGR
DSMYQAILPL RGKIINVEKA RIDRVLKNNE VQSIITAFGT GIHDEFDIAK LRYNKIIL
//
