ID Q8GJ82_MYCSM Unreviewed; 902 AA.
AC Q8GJ82;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative membrane protein {ECO:0000313|EMBL:AAN28686.1};
GN Name=tmptC {ECO:0000313|EMBL:AAN28686.1};
OS Mycolicibacterium smegmatis (Mycobacterium smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1772 {ECO:0000313|EMBL:AAN28686.1};
RN [1] {ECO:0000313|EMBL:AAN28686.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12368441;
RA Jeevarajah D., Patterson J.H., McConville M.J., Billman-Jacobe H.;
RT "Modification of glycopeptidolipids by an O-methyltransferase of
RT Mycobacterium smegmatis.";
RL Microbiology 148:3079-3087(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; AY138899; AAN28686.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8GJ82; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 142..269
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 873..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 97710 MW; C03A0EFD6BB18EDC CRC64;
MIVLEGQEPL GPDALDYYTG LISELRNDSK HVEHVQDLWG DRLTASSAQS ADGKAAYVQL
NLAGNQGTPL GDESVAAVRD LVARTPAPEG VSVYVTGAAP LVSDMQHSGN RSILKITAVT
VVIIFAMLLM VYRSVITVIL LLIMVGFEVA AARGIVAFLG ANEVFVLSTF AVNMLVFLAI
AAGTDYGIFF FGRYQEARAA GEDRETAYYS MYRGVTPVVM ASGLTIAGAI FCLTFTRLPY
FHTMGVPCAI GMLAAVAVAV TLVPAGVALA GRIGWLEPKR KMRVRRWRGI GTAIVRWPAP
ILVASLAVAL VGLLALPGYE TSYNDRDYIP ADIPANAGFA AADRHFSQAR MTPDILMVES
DHDMRNPTDF LVLNKIAKAI FKVRGVSRVQ GITRPEGTPI ERTSIPFLLS LQSAGQVQAT
NFQKQRIGDM LKQVDDMNMM IGVMKTTYGV LQELAATTHS LNGSTHELRD VARDLRGSIA
IFDDLLRPIR NYFYWEPHCY NIPICWSLRS IFDAMDGVDR LNDELQVLVD NMDRLDALVP
ELVAQFPEYI ASMETFRELT LTSYSTFSGL LQQMDEQTED VTAMGQAFDA AKNDDTFFLP
PEVFDNPDFK RAMTSFLSPD GKAARFIISH NGDPATPEGI SRVDQMQTAA VEALKGTPLT
DAQVYLAGTA PTAKDWKDGS TYDLLIAGIA AMCLIFIIML IVTRSFIAAL VIVGTVVLSL
GASFGLSVLL WQYILGIHLH WMVLAMSVII LLAVGSDYNL LLVSRIKEEV GAGINTGIVR
AMGGTGKVVT SAGLVFAGTM AAMVVSDLRI IGQIGTTIGL GLLFDTMIVR SFMTPSIAAL
LGRWFWWPQK VRPRPASALL EPYGPRPLVR ALLEGPSGAA SPGGPGGRLS DDDTPTGPMR
TR
//
