ID Q8GL61_9BACT Unreviewed; 263 AA.
AC Q8GL61;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Aminoglycoside-3'-adenylyltransferase {ECO:0000313|EMBL:AAN41437.1};
GN Name=aadA1 {ECO:0000313|EMBL:AAN41437.1};
OS uncultured bacterium.
OG Plasmid pSp7 {ECO:0000313|EMBL:AAN41437.1}.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:AAN41437.1};
RN [1] {ECO:0000313|EMBL:AAN41437.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pSp7 {ECO:0000313|EMBL:AAN41437.1};
RA Tennstedt T., Szczepanowski R., Braun S., Puehler A., Schlueter A.;
RT "Occurrence of integron-associated resistance gene cassettes located on
RT antibiotic resistance plasmids isolated from a wastewater treatment
RT plant.";
RL FEMS Microbiol. Ecol. 45:239-252(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672};
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DR EMBL; AY139602; AAN41437.1; -; Genomic_DNA.
DR RefSeq; WP_032490451.1; NG_052314.1.
DR AlphaFoldDB; Q8GL61; -.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Nucleotidyltransferase {ECO:0000313|EMBL:AAN41437.1};
KW Plasmid {ECO:0000313|EMBL:AAN41437.1};
KW Transferase {ECO:0000313|EMBL:AAN41437.1}.
FT DOMAIN 28..66
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 152..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 263 AA; 29272 MW; 04ABBFD0C682BA42 CRC64;
MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLGE
TTRRALINDL LETSASPGEG EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA
GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPARY QPVILEARQA YLGQEEDRLA
SRADQLEEFV HYVKGEITKV VGK
//