ID   Q8GNN0_STRHY            Unreviewed;       484 AA.
AC   Q8GNN0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=ShnA {ECO:0000313|EMBL:AAN63812.1};
OS   Streptomyces hygroscopicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX   NCBI_TaxID=1912 {ECO:0000313|EMBL:AAN63812.1};
RN   [1] {ECO:0000313|EMBL:AAN63812.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wang Y., Gao Q.;
RT   "Cloning of ansamycin-antibiotic biosynthetic genes from Streptomyces
RT   hygroscopicus.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAN63812.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Gao Q., Wang Y.;
RT   "Identification and analysis of two separate AHBA biosynthetic gene
RT   clusters in Streptomyces hygroscopicus 17997.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; AF506522; AAN63812.1; -; Genomic_DNA.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          326..401
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          444..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   484 AA;  50889 MW;  0BE8F5CDC31F1B7C CRC64;
     MGVLADVHAS GEPQVALRSG AVLVPRLARV ADTDRASTGR RLDPDGTALI TGGTGALGAL
     VARHLVVEHK IRSLVLVSRR GPDAPGAADL DAELTALGAR VRIVACDIAD REAAGELIAS
     VPRDAPLTAV VHTAGVLDGG VVTALTPERL DAVLRPKADA ALVLDELTRH LDVAAFVLFS
     SAAGTFGNPG QGNLAASNAY LDALAVRRRT AGLPATSVAW GVWDQTGISG DLGVADQRRM
     ARWGLAAHSA QEGLELFDAA LRAXDAVLVA AXXNFAGLRA QAASEPVHVL LRGLVRAGRR
     AAQQASSREG GLAGQLAATP PVQREQILLD LVRREVAAVL GYSTPRKVDP DRAFQDVGFT
     SVLAVELRNR LAGLAGIRLP ASIAFDHPTP RRMMRHLLAE LCPEDGSEPA DREDEIRRAL
     ATTPLSRFRE LGLMEQILHL VAHPSGESAA APDTAEPKQD AGPLIAEMDI DNLVKRAMEK
     ARKP
//