ID Q8GU00_HYDMC Unreviewed; 389 AA.
AC Q8GU00;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Chalcone synthase {ECO:0000313|EMBL:AAN76184.1};
GN Name=CHS1 {ECO:0000313|EMBL:AAN76184.1};
OS Hydrangea macrophylla (Bigleaf hydrangea) (Viburnum macrophyllum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; Cornales; Hydrangeaceae; Hydrangeeae; Hydrangea;
OC Hydrangea sect. Macrophyllae.
OX NCBI_TaxID=23110 {ECO:0000313|EMBL:AAN76184.1};
RN [1] {ECO:0000313|EMBL:AAN76184.1}
RP NUCLEOTIDE SEQUENCE.
RA Schroeder J.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAN76184.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12620338; DOI=10.1016/S0031-9422(02)00554-X;
RA Eckermann C., Schroder G., Eckermann S., Strack D., Schmidt J.,
RA Schneider B., Schroder J.;
RT "Stilbenecarboxylate biosynthesis: a new function in the family of chalcone
RT synthase-related proteins.";
RL Phytochemistry 62:271-286(2003).
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
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DR EMBL; AH012188; AAN76184.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8GU00; -.
DR SMR; Q8GU00; -.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF14; CHALCONE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003633};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003633}.
FT DOMAIN 5..228
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 238..387
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 164
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 389 AA; 42741 MW; 3F8E8BC906620AB8 CRC64;
MVTVEEVRKA QRAEGPATIL AIGTATPPNY VDQSTYPDFY FRVTNSEHKK ELKAKFQRMC
NNSQIKKCYM HLTEEILKLN PNICAYMVPS LDARQDMVVV EIPKLGKEAA TRAIKEWGQP
KSKITHLVFC TTSGVDMPGA DYQLTKLLGL RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN
NKGARVLVVC SEITAVTFRG PSDTHLDSLV GQALFGDGAR AVIIGSDPMP EVEKPLFEIV
SAAQTILPDS DGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLVEAFRPL DISDWNSIFW
IAHPGGPAIL DQVEKKLALK PEKLRATRNV LSDYGNMSSA CVLFIMDEMR KNSVYEGLMT
TGEGLEWGVL FGFGPGLTVE TVVLHGVST
//
