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Database: UniProt
Entry: Q8HZP2
LinkDB: Q8HZP2
Original site: Q8HZP2 
ID   BKRB1_MACMU             Reviewed;         352 AA.
AC   Q8HZP2; Q95L02;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   01-OCT-2014, entry version 64.
DE   RecName: Full=B1 bradykinin receptor;
DE            Short=B1R;
DE            Short=BK-1 receptor;
GN   Name=BDKRB1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Horlick R.A., Zhao J., Swanson R.N., Webb M.L., Strohl B.,
RA   Baldwin J.J., Auld D.S.;
RT   "Orthologs of human receptors and methods of use.";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hess F., Hey P.;
RT   "Molecular cloning of rhesus monkey B1 bradykinin receptor.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC       chronic pain and inflammation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF540785; AAN16464.1; -; Genomic_DNA.
DR   EMBL; AY045568; AAK95386.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q8HZP2; -.
DR   STRING; 9544.ENSMMUP00000032596; -.
DR   BindingDB; Q8HZP2; -.
DR   ChEMBL; CHEMBL1250405; -.
DR   eggNOG; NOG327312; -.
DR   HOVERGEN; HBG103183; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004947; F:bradykinin receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR001186; Brdyknn_1_rcpt.
DR   InterPro; IPR000496; Brdyknn_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00425; BRADYKININR.
DR   PRINTS; PR00993; BRADYKINNB1R.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
KW   Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    352       B1 bradykinin receptor.
FT                                /FTId=PRO_0000069183.
FT   TOPO_DOM      1     41       Extracellular. {ECO:0000255}.
FT   TRANSMEM     42     62       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     63     72       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     73     93       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     94    110       Extracellular. {ECO:0000255}.
FT   TRANSMEM    111    131       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    132    153       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    154    174       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    175    206       Extracellular. {ECO:0000255}.
FT   TRANSMEM    207    227       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    228    250       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    251    271       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    272    294       Extracellular. {ECO:0000255}.
FT   TRANSMEM    295    315       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    316    352       Cytoplasmic. {ECO:0000255}.
FT   LIPID       329    329       S-palmitoyl cysteine. {ECO:0000255}.
FT   CARBOHYD     13     13       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD     21     21       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    184    184       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    109    188       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   CONFLICT      8      8       E -> Q (in Ref. 2; AAK95386).
FT                                {ECO:0000305}.
FT   CONFLICT    314    314       V -> A (in Ref. 2; AAK95386).
FT                                {ECO:0000305}.
SQ   SEQUENCE   352 AA;  40246 MW;  9254149620ED896D CRC64;
     MASWPPLELQ SSNQSQLFPQ NATACDNAPE AWDLLHRVLP TFIISICSFG LLGNLFVLLV
     FLLPRRRLNV AEIYLANLAA SDLVFVLGLP FWAENIWNQF NWPFGALLCR VINGIIKANL
     FISIFLVVAI SQDRYCVLVH PMASRRRQRR RQARVTCVLI WVVGGLLSIP TFLLRSIQAV
     PDLNITACIL LLPHEAWHFA RIVELNILAF LLPLAAIIFF NYHILASLRG REEVSRTRCG
     GSKDSKTTAL ILTLVVAFLV CWAPYHFFAF LEFLFQVQAV RGCFWEDFID LGLQLANFLA
     FTNSSLNPVI YVFVGRLFRT KVWELYKQCT PKSLAPISSS HRKEIFQLFW RN
//
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