ID BKRB1_MACMU Reviewed; 352 AA.
AC Q8HZP2; Q95L02;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 01-MAY-2013, entry version 59.
DE RecName: Full=B1 bradykinin receptor;
DE Short=B1R;
DE Short=BK-1 receptor;
GN Name=BDKRB1;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Horlick R.A., Zhao J., Swanson R.N., Webb M.L., Strohl B.,
RA Baldwin J.J., Auld D.S.;
RT "Orthologs of human receptors and methods of use.";
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hess F., Hey P.;
RT "Molecular cloning of rhesus monkey B1 bradykinin receptor.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in
CC chronic pain and inflammation (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
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DR EMBL; AF540785; AAN16464.1; -; Genomic_DNA.
DR EMBL; AY045568; AAK95386.1; -; Genomic_DNA.
DR ProteinModelPortal; Q8HZP2; -.
DR STRING; 9544.ENSMMUP00000032596; -.
DR eggNOG; NOG327312; -.
DR HOVERGEN; HBG103183; -.
DR BindingDB; Q8HZP2; -.
DR ChEMBL; CHEMBL1250405; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004947; F:bradykinin receptor activity; IEA:InterPro.
DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:InterPro.
DR GO; GO:0006950; P:response to stress; IEA:InterPro.
DR InterPro; IPR001186; Brdyknn_1_rcpt.
DR InterPro; IPR000496; Brdyknn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00425; BRADYKININR.
DR PRINTS; PR00993; BRADYKINNB1R.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
KW Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 352 B1 bradykinin receptor.
FT /FTId=PRO_0000069183.
FT TOPO_DOM 1 41 Extracellular (Potential).
FT TRANSMEM 42 62 Helical; Name=1; (Potential).
FT TOPO_DOM 63 72 Cytoplasmic (Potential).
FT TRANSMEM 73 93 Helical; Name=2; (Potential).
FT TOPO_DOM 94 110 Extracellular (Potential).
FT TRANSMEM 111 131 Helical; Name=3; (Potential).
FT TOPO_DOM 132 153 Cytoplasmic (Potential).
FT TRANSMEM 154 174 Helical; Name=4; (Potential).
FT TOPO_DOM 175 206 Extracellular (Potential).
FT TRANSMEM 207 227 Helical; Name=5; (Potential).
FT TOPO_DOM 228 250 Cytoplasmic (Potential).
FT TRANSMEM 251 271 Helical; Name=6; (Potential).
FT TOPO_DOM 272 294 Extracellular (Potential).
FT TRANSMEM 295 315 Helical; Name=7; (Potential).
FT TOPO_DOM 316 352 Cytoplasmic (Potential).
FT LIPID 329 329 S-palmitoyl cysteine (Potential).
FT CARBOHYD 13 13 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
FT DISULFID 109 188 By similarity.
FT CONFLICT 8 8 E -> Q (in Ref. 2; AAK95386).
FT CONFLICT 314 314 V -> A (in Ref. 2; AAK95386).
SQ SEQUENCE 352 AA; 40246 MW; 9254149620ED896D CRC64;
MASWPPLELQ SSNQSQLFPQ NATACDNAPE AWDLLHRVLP TFIISICSFG LLGNLFVLLV
FLLPRRRLNV AEIYLANLAA SDLVFVLGLP FWAENIWNQF NWPFGALLCR VINGIIKANL
FISIFLVVAI SQDRYCVLVH PMASRRRQRR RQARVTCVLI WVVGGLLSIP TFLLRSIQAV
PDLNITACIL LLPHEAWHFA RIVELNILAF LLPLAAIIFF NYHILASLRG REEVSRTRCG
GSKDSKTTAL ILTLVVAFLV CWAPYHFFAF LEFLFQVQAV RGCFWEDFID LGLQLANFLA
FTNSSLNPVI YVFVGRLFRT KVWELYKQCT PKSLAPISSS HRKEIFQLFW RN
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