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Database: UniProt
Entry: Q8I2J3_PLAF7
LinkDB: Q8I2J3_PLAF7
Original site: Q8I2J3_PLAF7 
ID   Q8I2J3_PLAF7            Unreviewed;       570 AA.
AC   Q8I2J3;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   30-AUG-2017, entry version 95.
DE   SubName: Full=M18 aspartyl aminopeptidase {ECO:0000313|EMBL:CAD52000.1};
DE            EC=3.4.11.21 {ECO:0000313|EMBL:CAD52000.1};
GN   ORFNames=PF3D7_0932300 {ECO:0000313|EMBL:CAD52000.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD52000.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|EMBL:CAD52000.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000213|PDB:4EME}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-570 IN COMPLEX WITH ZINC,
RP   AND DISULFIDE BONDS.
RX   PubMed=22709581; DOI=10.1016/j.jmb.2012.06.006;
RA   Sivaraman K.K., Oellig C.A., Huynh K., Atkinson S.C., Poreba M.,
RA   Perugini M.A., Trenholme K.R., Gardiner D.L., Salvesen G., Drag M.,
RA   Dalton J.P., Whisstock J.C., McGowan S.;
RT   "X-ray crystal structure and specificity of the Plasmodium falciparum
RT   malaria aminopeptidase PfM18AAP.";
RL   J. Mol. Biol. 422:495-507(2012).
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|RuleBase:RU004386}.
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DR   EMBL; AL844508; CAD52000.1; -; Genomic_DNA.
DR   RefSeq; XP_001352189.1; XM_001352153.1.
DR   PDB; 4EME; X-ray; 2.60 A; A/B/C/D=2-570.
DR   PDBsum; 4EME; -.
DR   ProteinModelPortal; Q8I2J3; -.
DR   SMR; Q8I2J3; -.
DR   ChEMBL; CHEMBL1293263; -.
DR   MEROPS; M18.003; -.
DR   EnsemblProtists; CAD52000; CAD52000; PF3D7_0932300.
DR   GeneDB; PF3D7_0932300.1:pep; -.
DR   GeneID; 813594; -.
DR   KEGG; pfa:PFI1570c; -.
DR   EuPathDB; PlasmoDB:PF3D7_0932300; -.
DR   HOGENOM; HOG000253244; -.
DR   InParanoid; Q8I2J3; -.
DR   KO; K01267; -.
DR   OMA; CFDHEEI; -.
DR   PhylomeDB; Q8I2J3; -.
DR   BRENDA; 3.4.11.7; 4889.
DR   Proteomes; UP000001450; Chromosome 9.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006518; P:peptide metabolic process; IBA:GO_Central.
DR   InterPro; IPR001948; Peptidase_M18.
DR   Pfam; PF02127; Peptidase_M18; 2.
DR   PRINTS; PR00932; AMINO1PTASE.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:4EME};
KW   Aminopeptidase {ECO:0000256|RuleBase:RU004386,
KW   ECO:0000313|EMBL:CAD52000.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Hydrolase {ECO:0000256|RuleBase:RU004386,
KW   ECO:0000313|EMBL:CAD52000.1};
KW   Metal-binding {ECO:0000213|PDB:4EME, ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Zinc {ECO:0000213|PDB:4EME, ECO:0000256|RuleBase:RU004386}.
FT   METAL        86     86       Zinc 1; via tele nitrogen.
FT                                {ECO:0000213|PDB:4EME}.
FT   METAL       324    324       Zinc 1. {ECO:0000213|PDB:4EME}.
FT   METAL       324    324       Zinc 2. {ECO:0000213|PDB:4EME}.
FT   METAL       380    380       Zinc 2. {ECO:0000213|PDB:4EME}.
FT   METAL       434    434       Zinc 1. {ECO:0000213|PDB:4EME}.
FT   METAL       534    534       Zinc 2; via tele nitrogen.
FT                                {ECO:0000213|PDB:4EME}.
FT   DISULFID     26     58       {ECO:0000213|PDB:4EME}.
SQ   SEQUENCE   570 AA;  65635 MW;  A87094CCC675BF1C CRC64;
     MDKKAREYAQ DALKFIQRSG SNFLACKNLK ERLENNGFIN LSEGETWNLN KNEGYVLCKE
     NRNICGFFVG KNFNIDTGSI LISIGHIDSC ALKISPNNNV IKKKIHQINV ECYGSGLWHT
     WFDRSLGLSG QVLYKKGNKL VEKLIQINKS VLFLPSLAIH LQNRTRYDFS VKINYENHIK
     PIISTTLFNQ LNKCKRNNVH HDTILTTDTK FSHKENSQNK RDDQMCHSFN DKDVSNHNLD
     KNTIEHLTNQ QNEEKNKHTK DNPNSKDIVE HINTDNSYPL LYLLSKELNC KEEDILDFEL
     CLMDTQEPCF TGVYEEFIEG ARFDNLLGSF CVFEGFIELV NSIKNHTSNE NTNHTNNITN
     DINDNIHNNL YISIGYDHEE IGSLSEVGAR SYCTKNFIDR IISSVFKKEI HEKNLSVQEI
     YGNLVNRSFI LNVDMAHCSH PNYPETVQDN HQLFFHEGIA IKYNTNKNYV TSPLHASLIK
     RTFELYYNKY KQQIKYQNFM VKNDTPCGST VGSMVAANLS MPGIDIGIPQ LAMHSIREIA
     AVHDVFFLIK GVFAFYTYYN QVLSTCVHDK
//
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