ID Q8I497_CUPSA Unreviewed; 438 AA.
AC Q8I497;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=delta2 {ECO:0000313|EMBL:CAD45191.1};
OS Cupiennius salei (American wandering spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Cupiennius.
OX NCBI_TaxID=6928 {ECO:0000313|EMBL:CAD45191.1};
RN [1] {ECO:0000313|EMBL:CAD45191.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12403706; DOI=10.1242/dev.00109;
RA Stollewerk A.;
RT "Recruitment of cell groups through Delta/Notch signalling during spider
RT neurogenesis.";
RL Development 129:5339-5348(2002).
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AJ507290; CAD45191.1; -; mRNA.
DR AlphaFoldDB; Q8I497; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW ECO:0000256|RuleBase:RU280815}; Membrane {ECO:0000256|RuleBase:RU280815};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..438
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004308351"
FT DOMAIN 185..229
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 293..331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 333..370
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 372..408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 187..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 200..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 220..229
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 321..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 360..369
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 398..407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 438 AA; 48112 MW; 1EA01A5CDB9D04B2 CRC64;
MGTVCRSFIT ATATLFLILT AAHLQEVKPF GIFELNLVSY ENREGRDDIL GGCCSGRLGA
DGSCPPCPVY LRVCVKHYQA LVDPSSPCTF HEFVTPLLVA ANGTAEEDRG LQVLSDPDTM
TFDFNLTWLG EFSLIVEAWH PSERKGSNKV LVSRFIAQRT LKVGLAWTQD ELSTNQSTLK
LMYRVYCATN YYGPNCGNLC RPRDDKFGHY TCKEDGQKLC KPGWSGSYCD KALCLPGCHG
TCDLPDECKC RPGWLGKFCD TCTRYPGCIH GTCNQPWQCN CDEGWGGLFC DHDLNYCTNH
KPCQNGGTCT NTGQGSYTCN CTEEFMGVNC NILKNPCQKN PCRNNGICEN SSQGQYTCTC
APGFYGPHCE TTASICTKNP CENGGSCIHD PKGVICDCPP GFSGILCEKK DPVRCVSGHC
LNGKKNGRNR PYGSLFLF
//