ID Q8I513_PLAF7 Unreviewed; 256 AA.
AC Q8I513;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE SubName: Full=Mitochondrial carrier protein, putative {ECO:0000313|EMBL:CZT99572.1};
GN ORFNames=PF3D7_1241600 {ECO:0000313|EMBL:CZT99572.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99572.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT99572.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN999947; CZT99572.1; -; Genomic_DNA.
DR RefSeq; XP_001350804.1; XM_001350768.1.
DR AlphaFoldDB; Q8I513; -.
DR SMR; Q8I513; -.
DR TCDB; 2.A.29.18.8; the mitochondrial carrier (mc) family.
DR PaxDb; 5833-PFL2000w; -.
DR EnsemblProtists; CZT99572; CZT99572; PF3D7_1241600.
DR GeneID; 811452; -.
DR KEGG; pfa:PF3D7_1241600; -.
DR VEuPathDB; PlasmoDB:PF3D7_1241600; -.
DR HOGENOM; CLU_015166_3_0_1; -.
DR InParanoid; Q8I513; -.
DR OMA; NILYEEX; -.
DR OrthoDB; 199104at2759; -.
DR PhylomeDB; Q8I513; -.
DR Reactome; R-PFA-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:GeneDB.
DR GO; GO:0005739; C:mitochondrion; ISS:GeneDB.
DR GO; GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45667; S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN; 1.
DR PANTHER; PTHR45667:SF9; S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 1..73
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 177..256
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 256 AA; 28774 MW; 827B203EE4DF0D33 CRC64;
MEHLKNLITG AISGAIVDAV LFPIDYIKTN IQTNNSFSIY DPRKLYNGIL PTLIGTVPAS
AFFYCFYELS KKLLTDYNAN INKSSLYLIS TSIAEITACI IRLPFEILKQ NMQVSGNIST
LKAIYNISKK NDLPIYLLNS YLIMVAREIP FDCIQYFLWE SLKEKGKKDF KNISEIYPTL
TSALCGGIAG GISGFLTTPV DVIKSRQIIY GKSYIETIKD ISKGGFLSFY KGCYVRASYL
CFGGMIFFGC LRFFSF
//
