ID Q8I5T2_PLAF7 Unreviewed; 205 AA.
AC Q8I5T2;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE RecName: Full=Glutathione peroxidase {ECO:0000256|RuleBase:RU000499};
GN ORFNames=PF3D7_1212000 {ECO:0000313|EMBL:CZT99282.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99282.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT99282.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC {ECO:0000256|ARBA:ARBA00006926, ECO:0000256|RuleBase:RU000499}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN999947; CZT99282.1; -; Genomic_DNA.
DR RefSeq; XP_001350528.1; XM_001350492.1.
DR AlphaFoldDB; Q8I5T2; -.
DR SMR; Q8I5T2; -.
DR STRING; 36329.Q8I5T2; -.
DR PeroxiBase; 3969; PfaGPx01.
DR PaxDb; 5833-PFL0595c; -.
DR EnsemblProtists; CZT99282; CZT99282; PF3D7_1212000.
DR GeneID; 811172; -.
DR KEGG; pfa:PF3D7_1212000; -.
DR VEuPathDB; PlasmoDB:PF3D7_1212000; -.
DR HOGENOM; CLU_029507_0_1_1; -.
DR InParanoid; Q8I5T2; -.
DR OMA; TFPMTEK; -.
DR OrthoDB; 177208at2759; -.
DR PhylomeDB; Q8I5T2; -.
DR Reactome; R-PFA-2142712; Synthesis of 12-eicosatetraenoic acid derivatives.
DR Reactome; R-PFA-3299685; Detoxification of Reactive Oxygen Species.
DR Reactome; R-PFA-9018676; Biosynthesis of D-series resolvins.
DR Reactome; R-PFA-9018896; Biosynthesis of E-series 18(S)-resolvins.
DR Reactome; R-PFA-9020265; Biosynthesis of aspirin-triggered D-series resolvins.
DR Reactome; R-PFA-9023661; Biosynthesis of E-series 18(R)-resolvins.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0020011; C:apicoplast; IDA:GeneDB.
DR GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR GO; GO:0005739; C:mitochondrion; IDA:GeneDB.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
DR GO; GO:0008379; F:thioredoxin peroxidase activity; IDA:GeneDB.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00340; GSH_Peroxidase; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR11592; GLUTATHIONE PEROXIDASE; 1.
DR PANTHER; PTHR11592:SF27; GLUTATHIONE PEROXIDASE 8-RELATED; 1.
DR Pfam; PF00255; GSHPx; 1.
DR PIRSF; PIRSF000303; Glutathion_perox; 1.
DR PRINTS; PR01011; GLUTPROXDASE.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000499};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000256|RuleBase:RU000499};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 38..205
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT ACT_SITE 76
FT /evidence="ECO:0000256|PIRSR:PIRSR000303-1"
SQ SEQUENCE 205 AA; 23953 MW; FF69BB20E2894567 CRC64;
MFFSMFIKFI LPISFICYNF GKKFNMFSYF QKIKVSEQEL LSSIYDYEVK DLSGSNVSMS
KFKNKVLIIF NSASKCGLTK NHVEQFNKLH EKYNARGLEI LAFPTSQFLN QEFDNTKDIC
TFNEKNKIKY NMFSPIEVNG DNTHPLFKYL KKNCDSMHDE NGTLKSIGWN FGKFLVDKNG
EVVNYFSPKT NPLDLEKIII QLLQK
//