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Database: UniProt
Entry: Q8I6Y9_CAEEL
LinkDB: Q8I6Y9_CAEEL
Original site: Q8I6Y9_CAEEL 
ID   Q8I6Y9_CAEEL            Unreviewed;       886 AA.
AC   Q8I6Y9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 2.
DT   25-OCT-2017, entry version 121.
DE   SubName: Full=TRP (Transient receptor potential) channel family {ECO:0000313|EMBL:CCD73247.1};
GN   Name=trp-2 {ECO:0000313|EMBL:CCD73247.1,
GN   ECO:0000313|WormBase:R06B10.4b};
GN   ORFNames=CELE_R06B10.4 {ECO:0000313|EMBL:CCD73247.1}, R06B10.4
GN   {ECO:0000313|WormBase:R06B10.4b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD73247.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD73247.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD73247.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; BX284603; CCD73247.1; -; Genomic_DNA.
DR   RefSeq; NP_001022703.1; NM_001027532.3.
DR   UniGene; Cel.39156; -.
DR   ProteinModelPortal; Q8I6Y9; -.
DR   STRING; 6239.R06B10.4b; -.
DR   PaxDb; Q8I6Y9; -.
DR   EnsemblMetazoa; R06B10.4b; R06B10.4b; WBGene00006615.
DR   GeneID; 192056; -.
DR   KEGG; cel:CELE_R06B10.4; -.
DR   UCSC; R06B10.4a; c. elegans.
DR   CTD; 192056; -.
DR   WormBase; R06B10.4b; CE36447; WBGene00006615; trp-2.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   HOGENOM; HOG000020589; -.
DR   InParanoid; Q8I6Y9; -.
DR   KO; K04967; -.
DR   OMA; SCMKWRR; -.
DR   OrthoDB; EOG091G029I; -.
DR   PhylomeDB; Q8I6Y9; -.
DR   Reactome; R-CEL-3295583; TRP channels.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006615; -.
DR   ExpressionAtlas; Q8I6Y9; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:CCD73247.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    335    355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    376    395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    547    569       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    646    665       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      177    239       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      379    676       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   886 AA;  102217 MW;  C62D349E5342CB64 CRC64;
     MTSSEASEFR MIEDDDDVSN NVTWTESDNS RLREKQFLLS CERGDIGSVR KLLAGISTET
     FNINCLDPLG RNALLIAIEN ENIEMIELLL DHNIETGDAI LYAIGEENVE AVEIIVEHLE
     KMDKFDSERQ GVEITEHSAF TPDITPIVLA AHKDNYECIK LFLDKKGTVP HPHDVRCSCP
     ECYVAREEDS LRLSRSRINA YRALTSPSLI CLSARDPILY AFELSWELKR LSFIENEFRT
     DYEELSQKCQ KFCVHMLDQV RGSKELEVVL NHTTNAWHDV TSANYGNPEK LARLKLAIQL
     SQKRFVAHPN CQQLLLDIWY EGVESVRCTN FIYKLIFYIL GMLSFPLFSL VYLLAPHSSM
     GQFAKKPFIK FLSHSGSYIF FLILLIMASQ RMNVIDNILR TDDVDRKETR GPPPTIIECA
     IFLWVLGLIW VEIKQLWECG LYNYCRNLWN ILDFITNSLY LCTTALRVVA YVQVEQEALR
     ANSVHIARHL PRRDWDAWDP TLLSECFFAT ANIFSSLKLV HIFTVSPHLG PLKISLGRMV
     IDIVKFFMVY ALVLFAFACG LNQLLWYYAS MRQNECNLYE QYKNEKSLSY KYEHLKESCD
     DKYKSCSSIY HTAETLFWAL FGLVDLTHFR LKEDHFLSEW TGKTIFGSYC CCSIIVLLNM
     LIAMMSNSYQ YISDQADIEW KFARSRLFLE YFDDTATLPP PFNIVPSPKS IYYCLHYLTK
     KLCNCTKLQQ PSKQKSMRVE SKNLAIRQRP RKQLPENCAK NRYSGAQFHS RNKKKTAMAE
     RRLKNSALLL KEFPVPQMFK AGQRNMSISS IQSNGRLKPS FMPSSSKLSW SNLKVKASRL
     SKSKSIDTTH LDVTRLHALS KKSPLQKQAH TSFDTSSLND DTDELL
//
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