ID SODF_PLAF7 Reviewed; 198 AA.
AC Q8IAY6;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Superoxide dismutase [Fe];
DE EC=1.15.1.1;
DE AltName: Full=FeSOD;
GN Name=SODB; ORFNames=PF08_0071;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) IN COMPLEX WITH IRON IONS, CATALYTIC
RP ACTIVITY, AND SUBUNIT.
RX PubMed=17020617; DOI=10.1186/1472-6807-6-20;
RA Boucher I.W., Brzozowski A.M., Brannigan J.A., Schnick C., Smith D.J.,
RA Kyes S.A., Wilkinson A.J.;
RT "The crystal structure of superoxide dismutase from Plasmodium
RT falciparum.";
RL BMC Struct. Biol. 6:20-20(2006).
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological systems.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC Evidence={ECO:0000269|PubMed:17020617};
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Note=Binds 1 Fe cation per subunit.;
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:17020617}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC {ECO:0000305}.
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DR EMBL; AL844507; CAD51224.1; -; Genomic_DNA.
DR RefSeq; XP_001349375.1; XM_001349339.1.
DR PDB; 2BPI; X-ray; 2.52 A; A/B=1-198.
DR PDBsum; 2BPI; -.
DR AlphaFoldDB; Q8IAY6; -.
DR SMR; Q8IAY6; -.
DR IntAct; Q8IAY6; 1.
DR MINT; Q8IAY6; -.
DR STRING; 36329.Q8IAY6; -.
DR PaxDb; 5833-PF08_0071; -.
DR EnsemblProtists; CAD51224; CAD51224; PF3D7_0814900.
DR GeneID; 2655270; -.
DR KEGG; pfa:PF3D7_0814900; -.
DR VEuPathDB; PlasmoDB:PF3D7_0814900; -.
DR HOGENOM; CLU_031625_0_0_1; -.
DR InParanoid; Q8IAY6; -.
DR OMA; DSLINWD; -.
DR OrthoDB; 4839at2759; -.
DR PhylomeDB; Q8IAY6; -.
DR EvolutionaryTrace; Q8IAY6; -.
DR Proteomes; UP000001450; Chromosome 8.
DR GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004784; F:superoxide dismutase activity; ISO:GeneDB.
DR GO; GO:0006979; P:response to oxidative stress; ISS:GeneDB.
DR GO; GO:0006801; P:superoxide metabolic process; ISS:GeneDB.
DR Gene3D; 1.10.287.990; Fe,Mn superoxide dismutase (SOD) domain; 1.
DR Gene3D; 3.55.40.20; Iron/manganese superoxide dismutase, C-terminal domain; 1.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019833; Mn/Fe_SOD_BS.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR InterPro; IPR036314; SOD_C_sf.
DR PANTHER; PTHR42769; SUPEROXIDE DISMUTASE; 1.
DR PANTHER; PTHR42769:SF3; SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC; 1.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PIRSF; PIRSF000349; SODismutase; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF54719; Fe,Mn superoxide dismutase (SOD), C-terminal domain; 1.
DR SUPFAM; SSF46609; Fe,Mn superoxide dismutase (SOD), N-terminal domain; 1.
DR PROSITE; PS00088; SOD_MN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Iron; Metal-binding; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..198
FT /note="Superoxide dismutase [Fe]"
FT /id="PRO_0000290110"
FT BINDING 27
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT BINDING 74
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT BINDING 158
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT BINDING 162
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT TURN 12..18
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 21..29
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 31..43
FT /evidence="ECO:0007829|PDB:2BPI"
FT TURN 47..50
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 53..59
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 62..79
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 92..101
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 104..117
FT /evidence="ECO:0007829|PDB:2BPI"
FT STRAND 120..128
FT /evidence="ECO:0007829|PDB:2BPI"
FT STRAND 134..140
FT /evidence="ECO:0007829|PDB:2BPI"
FT TURN 145..149
FT /evidence="ECO:0007829|PDB:2BPI"
FT STRAND 152..158
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 161..163
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 165..168
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 172..179
FT /evidence="ECO:0007829|PDB:2BPI"
FT TURN 180..182
FT /evidence="ECO:0007829|PDB:2BPI"
FT HELIX 185..197
FT /evidence="ECO:0007829|PDB:2BPI"
SQ SEQUENCE 198 AA; 22734 MW; 0C636B66E6044D3B CRC64;
MVITLPKLKY ALNALSPHIS EETLNFHYNK HHAGYVNKLN TLIKDTPFAE KSLLDIVKES
SGAIFNNAAQ IWNHTFYWDS MGPDCGGEPH GEIKEKIQED FGSFNNFKEQ FSNILCGHFG
SGWGWLALNN NNKLVILQTH DAGNPIKDNT GIPILTCDIW EHAYYIDYRN DRASYVKAWW
NLVNWNFANE NLKKAMQK
//
