ID Q8IB14_PLAF7 Unreviewed; 99 AA.
AC Q8IB14;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=High mobility group protein B2 {ECO:0000313|EMBL:CAD51195.1};
GN ORFNames=PF3D7_0817900 {ECO:0000313|EMBL:CAD51195.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD51195.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0007829|PDB:2MRC}
RP STRUCTURE BY NMR OF 17-99.
RA Tang C., Barnwal R., Varani G.;
RT "NMR Structure and 1H, 13C and 15N Chemical Shift Assignments for High
RT mobility group protein from Plasmodium falciparum 3D7.";
RL Submitted (JUL-2014) to the PDB data bank.
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DR EMBL; AL844507; CAD51195.1; -; Genomic_DNA.
DR RefSeq; XP_001349346.1; XM_001349310.2.
DR PDB; 2MRC; NMR; -; A=17-99.
DR PDBsum; 2MRC; -.
DR AlphaFoldDB; Q8IB14; -.
DR SMR; Q8IB14; -.
DR IntAct; Q8IB14; 2.
DR STRING; 36329.Q8IB14; -.
DR PaxDb; 5833-MAL8P1-72; -.
DR EnsemblProtists; CAD51195; CAD51195; PF3D7_0817900.
DR GeneID; 2655422; -.
DR KEGG; pfa:PF3D7_0817900; -.
DR VEuPathDB; PlasmoDB:PF3D7_0817900; -.
DR HOGENOM; CLU_082854_10_3_1; -.
DR InParanoid; Q8IB14; -.
DR OMA; IAKVQRF; -.
DR OrthoDB; 1222485at2759; -.
DR PhylomeDB; Q8IB14; -.
DR Proteomes; UP000001450; Chromosome 8.
DR GO; GO:0005694; C:chromosome; IDA:GeneDB.
DR GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IDA:GeneDB.
DR GO; GO:0008301; F:DNA binding, bending; IDA:GeneDB.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; IDA:GeneDB.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; TAS:GeneDB.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; ISS:GeneDB.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR48112; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR PANTHER; PTHR48112:SF32; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2MRC};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 24..94
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 24..94
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 99 AA; 11535 MW; B5E3F00B533E9163 CRC64;
MASKSQKKVL KKQNKKKKKD PLAPKRALSA YMFYVKDKRL EIIKEKPELA KDVAQVGKLI
GEAWGQLSPA QKAPYEKKAQ LDKVRYSKEI EEYRKKNQE
//
