ID Q8IBN0_PLAF7 Unreviewed; 1221 AA.
AC Q8IBN0;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 112.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase, putative {ECO:0000313|EMBL:CAD50970.1};
DE EC=3.4.19.12 {ECO:0000313|EMBL:CAD50970.1};
GN ORFNames=PF3D7_0722300 {ECO:0000313|EMBL:CAD50970.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD50970.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL844506; CAD50970.1; -; Genomic_DNA.
DR RefSeq; XP_001349124.1; XM_001349088.1.
DR AlphaFoldDB; Q8IBN0; -.
DR SMR; Q8IBN0; -.
DR PaxDb; 5833-MAL7P1-120; -.
DR EnsemblProtists; CAD50970; CAD50970; PF3D7_0722300.
DR GeneID; 2655187; -.
DR KEGG; pfa:PF3D7_0722300; -.
DR VEuPathDB; PlasmoDB:PF3D7_0722300; -.
DR HOGENOM; CLU_291965_0_0_1; -.
DR InParanoid; Q8IBN0; -.
DR OMA; HRSHMLF; -.
DR OrthoDB; 123540at2759; -.
DR PhylomeDB; Q8IBN0; -.
DR Proteomes; UP000001450; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR24007; BRCA1-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR24007:SF7; BRCA1-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SMART; SM00290; ZnF_UBP; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:CAD50970.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00502}.
FT DOMAIN 871..982
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
FT REGION 215..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..135
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 215..230
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 145492 MW; B311CD87BB8199D2 CRC64;
MFHLIVYSDE SLQKVKRSLN VFENIYDQNG NKFEKSVEQN IKKCMDLDVP KYIHKLIDDE
NKDYKEYINE DIYNFYLRKD IIQFFTCNLI QLYIKDTKNC DLYLIDECEE EKKEKEKKES
KCKDDKQKYK NTQNLFKKEK HALDENNVLS SSNNTDDISV GINLPLHRSH ILLILSLPTY
YTFYEFFLLI QGFMNFIVHI KIFKLNGYLN FLKKKKKKKK KKKKKKFNNK NNHNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NSNNNNYYYY NNCCTYSCCI DKMNKKNIKG
NIKKKRTQNI HGDTQTNSYN DNTKPQSKGK QKVNTLNNES NTYIHNKELC KLNNKNYNKF
AHVEKKEQKC YSENMYTHNN IYDDHLNSYD HMDDSSISSG SYLYEDYIKN VSLRQQENKS
LNIRVKDNSK DRYMDNQNVL DLLHVNNDIN NNNIISNINN NINGNDYNCC HKKNSLNYYN
FLHTDKLLSS YNKMYHYIKK NLKKKKKIHT YSILIFFKTQ IYADMFYKKF HCRNLSSFMC
RNVSQKNVKN FYDNWYIYCA FVNLIYYILN YKENIENVGT NQSTRGYILN KNVSSGMSSD
TYDDISDDIY DDISDDISDD IYDDIYDDIS NNLRDNVGIP CAEKEMPSKY LNTSNRKINM
KDHIYSSQLF NINKYEKFIK SIIIDTKICI STCLLCMELL DNDIFLLLTR NEKICINKKR
NNNYYEYINL SCNVCTLIFF YDISSKLFNS DFCDILKTKN LNQQQFVGYL ENLIFLSKDN
MLVGQNENND KTNGGDKTNQ CDKTNQCDKT NQCDKTNQCD KTNQCDKTNQ CDKTNQCDKT
NQCDKTNQCG DKLPNDCSLI PMNHSDHKNK CVIKHSYKIF LNKREDVILK VLSLNNMFNK
LKCKNCNNVD DIWLCLTCSN VGCGRYHKRH AQMHSSLFNH YYCINMKTKK IWNYILDTYI
EERVHKNLED ITTMHSENSY DEFNKNKSNK IHSDNKNKSK KKMIPNNYHN NRSYYNIHTN
EKKKKQKKNF HLLYYDNNYI DDFSIFDQEY PLCDYNKKIY YKIYDIFTND IYINDNLKNE
LLYILYSQLS HESNIYNNIL IELQYIYLNK LEHPKNIMKN VTEKIMELQI QNNKINLLCT
HLASSIKKNN NLKNSLQEKI KFYRNINNNI ILHKKNNNFN NSSNKNRNKE KMDDKDIKKI
HNLDQTIKQL QEQVDALLTN L
//
