ID Q8IJ98_PLAF7 Unreviewed; 257 AA.
AC Q8IJ98;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=RNA methyltransferase, putative {ECO:0000313|EMBL:CZT98563.1};
DE EC=2.1.1.34 {ECO:0000313|EMBL:CZT98563.1};
GN ORFNames=PF3D7_1030700 {ECO:0000313|EMBL:CZT98563.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98563.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT98563.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999944; CZT98563.1; -; Genomic_DNA.
DR RefSeq; XP_001347584.1; XM_001347548.1.
DR AlphaFoldDB; Q8IJ98; -.
DR SMR; Q8IJ98; -.
DR STRING; 36329.Q8IJ98; -.
DR PaxDb; 5833-PF10_0300; -.
DR EnsemblProtists; CZT98563; CZT98563; PF3D7_1030700.
DR GeneID; 810457; -.
DR KEGG; pfa:PF3D7_1030700; -.
DR VEuPathDB; PlasmoDB:PF3D7_1030700; -.
DR HOGENOM; CLU_094787_0_0_1; -.
DR InParanoid; Q8IJ98; -.
DR OMA; CAIILHH; -.
DR OrthoDB; 5485891at2759; -.
DR PhylomeDB; Q8IJ98; -.
DR Proteomes; UP000001450; Chromosome 10.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0141100; F:tRNA (guanine(18)-2'-O)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18096; SpoU-like; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR43191:SF7; OBP33PEP LIKE PROTEIN; 1.
DR PANTHER; PTHR43191; RRNA METHYLTRANSFERASE 3; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:CZT98563.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transferase {ECO:0000313|EMBL:CZT98563.1}.
FT DOMAIN 53..192
FT /note="tRNA/rRNA methyltransferase SpoU type"
FT /evidence="ECO:0000259|Pfam:PF00588"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 29978 MW; 5A44F67A9869126E CRC64;
MKTEEKKSLQ EKEENNCNDD NLPTNVDIND NNMNNISYIN DKLKKDSYEK IKTYVVIYNI
GKKKNVGCIV RSCVAFNVHK IFIVGKRKKE INFFGNMGTY DYITIEYFDN IYELKEYLTK
HDILLYACEI SVNALSITTN PYEHKDTAFL FGNEGTGIHD NVLKICDKII YIPQYGKGTA
SLNVSVSCAI ILQNFAVWAN YEQTEIKNKK FIVQKKMSKL QKYLNPTDDM LKQIHFKRSL
RSQKKKENHI ISFENFI
//
