ID Q8ILE7_PLAF7 Unreviewed; 874 AA.
AC Q8ILE7;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 2.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Apyrase, putative {ECO:0000313|EMBL:CZU00015.1};
DE EC=3.6.1.5 {ECO:0000313|EMBL:CZU00015.1};
GN ORFNames=PF3D7_1431800 {ECO:0000313|EMBL:CZU00015.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZU00015.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZU00015.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR EMBL; LN999946; CZU00015.1; -; Genomic_DNA.
DR RefSeq; XP_001348471.2; XM_001348435.2.
DR AlphaFoldDB; Q8ILE7; -.
DR STRING; 36329.Q8ILE7; -.
DR PaxDb; 5833-PF14_0297; -.
DR EnsemblProtists; CZU00015; CZU00015; PF3D7_1431800.
DR GeneID; 811879; -.
DR KEGG; pfa:PF3D7_1431800; -.
DR VEuPathDB; PlasmoDB:PF3D7_1431800; -.
DR HOGENOM; CLU_328867_0_0_1; -.
DR InParanoid; Q8ILE7; -.
DR OMA; MCIILAM; -.
DR OrthoDB; 204457at2759; -.
DR Reactome; R-PFA-8850843; Phosphate bond hydrolysis by NTPDase proteins.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004050; F:apyrase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IBA:GO_Central.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 2.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF83; NTPASE, ISOFORM F; 1.
DR Pfam; PF01150; GDA1_CD39; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000313|EMBL:CZU00015.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 216
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 246..250
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 874 AA; 105033 MW; 59159A8D0EFAC046 CRC64;
MENLIGTPLI EKKKKESHIS IRKDKKLNDI EGEKKEKKIK ERLFLCLICL LVIIWLIYFC
YKNHIFLSYL QNEKEYGIII DAGSNGTRIH LFEWKKREYE LSNKKEENNL IELKEIFNAK
VKKSISTISY NEIKDILIYL INKVIDHLIE KKIYVYNKQK WKSYPFYFQA TGGMRNLKQE
DRNLRMKYIK NILSNDNYNP FYFLNEYARI LSGEEEGIYG WLAVNNLLNS IFSKPNNTYG
AIDLGGSSTQ ITFYPMDHNI LENYNSILLN NILIRLYSHS FIGYGWIDSL FRVNIYLCLE
IIKKLSTRNI KNIYQLENYY DDYINDYFYN NLPNYNWFFY STKKIINNNK ENYNHHNYEN
INYDVNKRNY PYNNFQQKYI HTNPKKGNYT KGNINNSNKS YKNLSNILLQ EIVKYIQHSQ
NDYPYSSLTD IYDYTYNIYD EKPYDIENFI KTIKNFNRHS KEDTIMLVQN PCLPYPYEMK
ITFPTYNLVT SQFVILKKNS RNEIGNINDI KNDGNNYTQN DDNNYTQNDG NYYRQNVGNY
YRHNHNINDV YELNSSESYD NFISNFVLKL KIINNNMSLM DNIYEDFKNK GYLNNVLKKV
NDNKISNTLK NEIIKRLFEK IINEKIKKLY INITVRIVGS NDFKKCLENT KKLFYEQPCF
LSSCSFNGIY QPNLENNKFV LHGQFKKVIT YLGFKKYVDL NQMKIYIQKL CNMNLYELTY
NMSNKIMHNQ IPTFCWKSIW SYSLLFYGFK FKETTKLLII NDNTNISYDS SSTSQASKQF
YKRVENKEQN NYLHDKTNYN NEYNLNNKID NISWTHGSMI YQINIFQERF NSRKYKLYSE
VFFVLFLIIF IILIILGGYI FKFKEILNKK YRFL
//