ID Q8ILF2_PLAF7 Unreviewed; 833 AA.
AC Q8ILF2;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Large subunit GTPase 1, putative {ECO:0000313|EMBL:CZU00010.1};
DE EC=3.6.1.- {ECO:0000313|EMBL:CZU00010.1};
GN ORFNames=PF3D7_1431300 {ECO:0000313|EMBL:CZU00010.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZU00010.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZU00010.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999946; CZU00010.1; -; Genomic_DNA.
DR RefSeq; XP_001348466.1; XM_001348430.1.
DR AlphaFoldDB; Q8ILF2; -.
DR IntAct; Q8ILF2; 1.
DR STRING; 36329.Q8ILF2; -.
DR PaxDb; 5833-PF14_0292; -.
DR EnsemblProtists; CZU00010; CZU00010; PF3D7_1431300.
DR GeneID; 811874; -.
DR KEGG; pfa:PF3D7_1431300; -.
DR VEuPathDB; PlasmoDB:PF3D7_1431300; -.
DR HOGENOM; CLU_363509_0_0_1; -.
DR InParanoid; Q8ILF2; -.
DR OMA; MDNIDDM; -.
DR OrthoDB; 130417at2759; -.
DR PhylomeDB; Q8ILF2; -.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR CDD; cd01857; HSR1_MMR1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR043358; GNL1-like.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45709:SF2; LARGE SUBUNIT GTPASE 1 HOMOLOG; 1.
DR PANTHER; PTHR45709; LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000313|EMBL:CZU00010.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT DOMAIN 601..657
FT /note="G"
FT /evidence="ECO:0000259|Pfam:PF01926"
FT REGION 161..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..262
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 98316 MW; 21F509C982BFC200 CRC64;
MAVLNKNRRK VDNKFMGRSL MRNKLRHKEI SDNILYSQIG NDNEVVKKNK KLSILNKDSL
DDFLDNQLII NNVEVSKVFL KKYEIKEKKN YGTNKLNTKD NIQNIVLPIP GRALFLKKDD
KIHILMKKKE EKEMEKKRKK KKNYKNKISF LMSGKSLIPL NVRVPKGDSS EKNKTKKIKK
KKLDGINGKG GDDNDIEDKE VEDNEVDDDN DVEDNDVDDD NDVEDNEVDD DNDDDNDVDV
DNDVEDNDDM DNIDDMDNID DMDNIDDMDN IDDMDNIDDM DNIDDMDNNY DIDNNDDINN
NDDINNIDDI NNINDNINDY ENDYNYKYLY MYERLGEKYK RLNTNNSRLN KESIDKYEHE
YFIEWRKLLS EIEEKEGYYV TPYEKNIEYW KQLWRVIEKS HVLFYILDVR NPLFFYCPGL
EYYIKKVDKR KKLILILNKA DFLTYEERKI WAEYFEKKKV PFVFFSALRE LYHQNKITIE
NMPCDNIPKR EDFMGDIYDN NNNMNGKQND DDDDDDEDYI IHNKTNIKNV FDLYNNIDEE
KKDIINVGFG NLSYEQKKND NTDILSVNDL INLIKKIKKE IKEFYHDIEI ETFSSIPKFM
IGFIGFPNVG KSSIINCLIG KKKVSVSRQP GKTKHFQTIT LKHFPFSLCD CPGLIFPSLV
FNKNDLIING VFSIDHFKGD VVTLVQIICN IIPFKLCNNY KIDTNIIHQY LNEKGHISYF
LDASEFLKKF CTFRKFVSGG KGGQLNFSHA TRIIIHDFIS GKLLYNFLPD YFKKTSHIYC
KNYIHQTAMD NILDNELLTE SNANEEILTT KRKFRYMQKK MMKGKNVIKC DKV
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