ID Q8IRV8_DROME Unreviewed; 3887 AA.
AC Q8IRV8;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 3.
DT 27-MAR-2024, entry version 174.
DE SubName: Full=Terribly reduced optic lobes, isoform AO {ECO:0000313|EMBL:AAN09078.3};
GN Name=trol {ECO:0000313|EMBL:AAN09078.3,
GN ECO:0000313|FlyBase:FBgn0284408};
GN Synonyms=anon-WO0153538.72 {ECO:0000313|EMBL:AAN09078.3},
GN BcDNA:GM02481 {ECO:0000313|EMBL:AAN09078.3}, CG12497
GN {ECO:0000313|EMBL:AAN09078.3}, CG33675 {ECO:0000313|EMBL:AAN09078.3},
GN CG7981 {ECO:0000313|EMBL:AAN09078.3}, CT23996
GN {ECO:0000313|EMBL:AAN09078.3}, Dmel\CG33950
GN {ECO:0000313|EMBL:AAN09078.3}, EG:BACR25B3.1
GN {ECO:0000313|EMBL:AAN09078.3}, EG:BACR25B3.10
GN {ECO:0000313|EMBL:AAN09078.3}, EG:BACR25B3.11
GN {ECO:0000313|EMBL:AAN09078.3}, EG:BACR25B3.2
GN {ECO:0000313|EMBL:AAN09078.3}, GC7891 {ECO:0000313|EMBL:AAN09078.3},
GN l(1)3Ac {ECO:0000313|EMBL:AAN09078.3}, l(1)9-96
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0019
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0021
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0023
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0181
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0211
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0271
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0374
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)G0412
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)trol {ECO:0000313|EMBL:AAN09078.3},
GN l(1)VA51 {ECO:0000313|EMBL:AAN09078.3}, l(1)zw1
GN {ECO:0000313|EMBL:AAN09078.3}, l(1)zwl {ECO:0000313|EMBL:AAN09078.3},
GN MRE7 {ECO:0000313|EMBL:AAN09078.3}, Pcan
GN {ECO:0000313|EMBL:AAN09078.3}, pcan {ECO:0000313|EMBL:AAN09078.3}, Pcn
GN {ECO:0000313|EMBL:AAN09078.3}, TROL {ECO:0000313|EMBL:AAN09078.3},
GN Trol {ECO:0000313|EMBL:AAN09078.3}, Trol-A
GN {ECO:0000313|EMBL:AAN09078.3}, Trol-B {ECO:0000313|EMBL:AAN09078.3},
GN Troll {ECO:0000313|EMBL:AAN09078.3}, troll
GN {ECO:0000313|EMBL:AAN09078.3}, ZW-1 {ECO:0000313|EMBL:AAN09078.3},
GN zw-1 {ECO:0000313|EMBL:AAN09078.3}, zw1 {ECO:0000313|EMBL:AAN09078.3};
GN ORFNames=CG33950 {ECO:0000313|EMBL:AAN09078.3,
GN ECO:0000313|FlyBase:FBgn0284408}, Dmel_CG33950
GN {ECO:0000313|EMBL:AAN09078.3};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AAN09078.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AE014298; AAN09078.3; -; Genomic_DNA.
DR RefSeq; NP_001027035.3; NM_001031864.3.
DR IntAct; Q8IRV8; 9.
DR EnsemblMetazoa; FBtr0342814; FBpp0309650; FBgn0284408.
DR GeneID; 45320; -.
DR UCSC; CG33950-RE; d. melanogaster.
DR AGR; FB:FBgn0284408; -.
DR CTD; 45320; -.
DR FlyBase; FBgn0284408; trol.
DR VEuPathDB; VectorBase:FBgn0284408; -.
DR GeneTree; ENSGT00940000156670; -.
DR OrthoDB; 2877710at2759; -.
DR BioGRID-ORCS; 45320; 0 hits in 3 CRISPR screens.
DR ChiTaRS; trol; fly.
DR GenomeRNAi; 45320; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0284408; Expressed in oviduct (Drosophila) and 54 other cell types or tissues.
DR ExpressionAtlas; Q8IRV8; baseline and differential.
DR GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007415; P:defasciculation of motor neuron axon; IMP:FlyBase.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IMP:FlyBase.
DR GO; GO:0008045; P:motor neuron axon guidance; IMP:FlyBase.
DR GO; GO:2001262; P:positive regulation of semaphorin-plexin signaling pathway; IGI:FlyBase.
DR GO; GO:0072347; P:response to anesthetic; IMP:FlyBase.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00055; EGF_Lam; 4.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05743; Ig_Perlecan_like; 1.
DR CDD; cd00110; LamG; 3.
DR CDD; cd00112; LDLa; 11.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 12.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF253; NEURAL CELL ADHESION MOLECULE; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 7.
DR Pfam; PF00052; Laminin_B; 3.
DR Pfam; PF00053; Laminin_EGF; 7.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00409; IG; 13.
DR SMART; SM00408; IGc2; 13.
DR SMART; SM00281; LamB; 3.
DR SMART; SM00282; LamG; 3.
DR SMART; SM00192; LDLa; 12.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 13.
DR SUPFAM; SSF57424; LDL receptor-like module; 11.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS50835; IG_LIKE; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR PROSITE; PS51115; LAMININ_IVA; 3.
DR PROSITE; PS01209; LDLRA_1; 6.
DR PROSITE; PS50068; LDLRA_2; 12.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q8IRV8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 771..858
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 995..1084
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1137..1315
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1371..1426
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1505..1686
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1721..1770
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1861..2036
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 2113..2204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2215..2297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2309..2400
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2413..2495
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2502..2589
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2591..2678
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2798..2882
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2893..2979
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2997..3090
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3095..3177
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3183..3360
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3356..3394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3396..3431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3440..3614
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3648..3684
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3690..3872
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 130..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2681..2715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..484
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2681..2697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2698..2715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 386..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 425..440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 492..504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 499..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 542..560
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 593..608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 636..651
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 660..678
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 672..687
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 688..700
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 695..713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 707..722
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 728..740
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 735..753
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 747..762
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 875..887
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 882..900
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 894..909
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 915..927
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 922..940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 934..949
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 958..970
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 965..983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 977..992
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1397..1406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1740..1749
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 3365..3382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3384..3393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3400..3410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3421..3430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3674..3683
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3845..3872
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 3887 AA; 430282 MW; 428BA8EC0286F0D6 CRC64;
MMGSPGSQAS AIATSVGIRS GRRGQAGGSL LLRLLAVTFV LAACHAPLLT NAKQISNLGD
DQDFMLADDE SLQGINDSEW QLMGDDIDDG LLDDVDETLK PMETKSEEED LPTGNWFSQS
VHRVRRSINR LFGSDDNQER GRRQQRERSQ RNRDAINRQK ELRRRQKEDH NRWKQMRMER
QLEKQRLVKR TNHVVFNRAT DPRKRASDLY DENEASGYHE EDTTLYRTYF VVNEPYDNEY
RDRESVQFQN LQKLLDDDLR NFFHSNYEGN DDEEQEIRST LERVEPTNDN FKIRVQLRIE
LPTSVNDFGS KLQQQLNVYN RIENLSAATD GVFSFTESSD IEEEAIDVTL PQEEVEGSGS
DDSSCRGDAT FTCPRSGKTI CDEMRCDREI QCPDGEDEEY CNYPNVCTED QFKCDDKCLE
LKKRCDGSID CLDQTDEAGC INAPEPEPEP EPEPEPEPES EPEAEPEPEP EPEPESEPEQ
EPEPQVPEAN ECQANEFRCN NGDCIDARKR CNNVSDCSEG EDENEECHSP PQTCLENIEF
ACHNRDCISI ESVCDGIPDC GRNEDEDDAL CKCSGDKYKC QRGGGCIPKS QVCDGKPQCH
DRSDESACPT TRLKPSDCSP EQFYCDESCY NRSVRCNGHV DCSDGSDEVG CSLPCPQHQC
PSGRCYTESE RCDRHRHCED GSDEANCCYA NQFRCNNGDC VSGSAPCNGY SECSDHSDEL
NCGGTQECLP NQFRCNSGQC VSSSVRCNGR TDCQDSSDEQ NCAADSNDRR PNQLNLKTYP
DSQIIKESRE VIFRCRDEGP ARAKVKWSRP GGRPLPPGFT DRNGRLEIPN IRVEDAGTYV
CEAVGYASYI PGQQVTVNLN VERYNDVGSR PESACTEYQA TCMNGECIDK SSICDGNPDC
SDASDEQSCS LGLKCQPNQF MCSNSKCVDR TWRCDGENDC GDNSDETSCD PEPSGAPCRY
NEFQCRSGHC IPKSFQCDNV PDCTDGTDEV GCMAPLPIRP PPQSVSLLEY EVLELTCVAT
GTPTPTIVWR LNWGHVPDKC ESKSYGGTGT LRCPDMRPQD SGAYSCEIIN TRGTHFVNPD
TIVTVRPVRT DVCEAGFFNM LARKAEECVQ CFCFGVAKAC DSANLFTYAI HPPILSHRVV
SVELSPLRQI VINEAAPGQD LLTLLHGVQF RATNVHFSGR ETPYLALPAD YMGNQLKSYG
GNLRYEVNYR GSGRPVNGPD VIITGNRFTL TYRVRTQPGQ NNRVSIPFVP GGWQKPDGRK
ASREEIMMIL ANVDNILIRL GYLDSTAREV DLINIALDSA GTADKGLGSA SLVEKCQCPP
GYVGDSCESC ASGYVRQPGG PWLGHCVPFI PDSCPSGTYG DPRRGVPCKE CPCPLTGSNN
FASGCQQSPD GDVVCRCNEG YTGRRCEQCA AGYQGNPLAA GGICRRIPDT SCNVDGTYSV
HSNGTCQCKD SVIGEQCDTC KSKSFHLNSF TYTGCIECFC SGVGLDCDSS TWYRDQVTST
FGRSRVDHGF VLVTNYMQPT PDTVPVSMAA EPNALSFIGS ADQSGNTLYW SLPAAFLGNK
LSSYGGKLTY TLSYSPLPNG IMSRNSAPDV VIKSGEDLRL IHYRKSQVVP SVANTYSVEI
KESAWQRGDE VVANREHVLM ALSDITAIYI KATYTTSTKE ASLRQVTLDV ATPTNLGTPR
AVEVEQCRCP EGYLGLSCEQ CAPGYARDPE GGIYLGLCRP CECNGHSKYC NSDTGDCEEC
SDNTEGPSCE RCAAGYVGDA TRGTIYDCQP DEGYPIPSPP APGNQTLECT AYCQIEGIYD
CRGNECLCKR NVIGDQCDQC RPGTYGLSAQ NQDGCKECYC SGLASQCRSA ALYRQLIPVD
FILNAPLITD ESGAVQDTEN LIPDISRNMY TYTHTSYLPK YWSLRGSVLG NQLFSYGGRL
SYSLIVESYG NYERGHDIVL IGNGLKLIWS RPDGNENQEE YNVRLHEDEQ WTRQDRESAR
PASRSDFMTV LSDLQHILIR ATPRVPTQST SIGNVILESA VTTRTPGATH ASDIELCQCP
SGYVGTSCES CAPLHYRDAS GSCSLCPCDV SNTESCDLVS GGYVECRCKA RWKGDRCREI
DTNDPTDIGT EDPVLTQIIV SIQKPEITIV PVGGSMTLSC SGRMRWSNSP VIVNWYKENS
RLPENVEVQG GNLYLYDLQV SDSGVYICQA VNNETASVFK DTVSITITKK DQLSPAEIVN
LPSHVTFEEY VNNEIICEVL GNPAPRVTWA RVDGHADAQS TRTYDNRLIF DSPRKSDEGR
YRCQAENDQN RDEKYVIVYV QSNPPQPPPQ QDRLYITPEE INGLAGESFQ LNCQFTSVAS
LRYDWSHNGR SLSSSPARNV EIRGNTLEVR DASESDSGVY TCVAYDVRTR RNFTESARVN
IDRREEQPFG NKPIIESLEQ NILIIQGEDY SITCEASGSP YPSIKWAKVH DFMPENVHIS
GNVLTIYGAR FENRGVYSCV AENDHGSDLS STSIDIEPRE RPSVKIVSAP LQTFSVGAPA
SLYCTVEGIP DPTVEWVRVD GQPLSPRHKI QSPGYMVIDD IQLEDSGDYE CRAKNIVGEA
TGVATITVQE PTLVQIIPDN RDLRLTEGDE LSLTCVGSGV PNPEVEWVNE MALKRDLYSP
PSNTAILKIY RVTKADAGIY TCHGKNEAGS DEAHVRVEVQ ERRGDIGGVD DDSDRDPINY
NPPQQQNPGI HQPGSNQLLA TDIGDNVTLT CDMFQPLNTR WERVDGAPLP RNAYTIKNRL
EIVRVEQQNL GQYRCNGIGR DGNVKTYFVK ELVLMPLPRI RFYPNIPLTV EAGQNLDVHC
QVENVRPEDV HWSTDNNRPL PSSVRIVGSV LRFVSITQAA AGEYRCSAFN QYGNRSQIAR
VAVKKPADFH QVPQSQLQRH REGENIQLQC TVTDQYGVRA QDNVEFNWFR DDRRPLPNNA
RTDSQILVLT NLRPEDAGRY ICNSYDVDRG QQLPEVSIDL QVLTATPPPN SPIYLPPQLP
AKSRDYSLKL DDQSSNLRAG ESTDVECYSS DDTYTDVVWE RSDGAPLSNN VRQVGNRLVI
SNVSPSDAGN YVCKCKTDEG DLYTTSYKLE VEDQPHELKS SKIVYAKVGA NADLQCGADE
SRQPTYRWSR QYGQLQAGRS LMNEKLSLDS VQANDAGTYI CTAQYADGET ADFPNILVVT
GAIPQFRQEP RSYMSFPTLP NSSFKFNFEL TFRPENGDGL LLFNGQTRGS GDYIALSLKD
RYAEFRFDFG GKPMLVRAEE PLALNEWHTV RVSRFKRDGY IQVDEQHPVA FPTLQQIPQL
DLIEDLYIGG VPNWELLPAD AVSQQVGFVG CISRLTLQGR TVELIREAKY KEGITDCRPC
AQGPCQNKGV CLESQTEQAY TCICQPGWTG RDCAIEGTQC TPGVCGAGRC ENTENDMECL
CPLNRSGDRC QYNEILNEHS LNFKGNSFAA YGTPKVTKVN ITLSVRPASL EDSVILYTAE
STLPSGDYLA LVLRGGHAEL LINTAARLDP VVVRSAEPLP LNRWTRIEIR RRLGEGILRV
GDGPERKAKA PGSDRILSLK THLYVGGYDR STVKVNRDVN ITKGFDGCIS RLYNFQKPVN
LLADIKDAAN IQSCGETNMI GGDEDSDNEP PVPPPTPDVH ENELQPYAMA PCASDPCENG
GSCSEQEDVA VCSCPFGFSG KHCQEHLQLG FNASFRGDGY VELNRSHFQP ALEQSYTSMG
IVFTTNKPNG LLFWWGQEAG EEYTGQDFIA AAVVDGYVEY SMRLDGEEAV IRNSDIRVDN
GERHIVIAKR DENTAILEVD RMLHSGETRP TSKKSMKLPG NVFVGGAPDL EVFTGFRYKH
NLNGCIVVVE GETVGQINLS SAAVNGVNAN VCPANDDPLG GTEPPVV
//
