ID Q8ISW3_DROAT Unreviewed; 508 AA.
AC Q8ISW3;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Xanthine dehydrogenase {ECO:0000313|EMBL:AAN34744.1};
DE Flags: Fragment;
GN Name=ry {ECO:0000313|FlyBase:FBgn0020209};
GN Synonyms=Xdh {ECO:0000313|EMBL:AAN34744.1};
OS Drosophila athabasca (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7248 {ECO:0000313|EMBL:AAN34744.1};
RN [1] {ECO:0000313|EMBL:AAN34744.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=2 {ECO:0000313|EMBL:AAN34744.1};
RX PubMed=12524344;
RA Begun D.J., Whitley P.;
RT "Molecular population genetics of Xdh and the evolution of base composition
RT in Drosophila.";
RL Genetics 162:1725-1735(2002).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
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DR EMBL; AF543156; AAN34744.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ISW3; -.
DR FlyBase; FBgn0020209; Dath\ry.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.90.1170.50; Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead; 1.
DR Gene3D; 3.30.390.50; CO dehydrogenase flavoprotein, C-terminal domain; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR000674; Ald_Oxase/Xan_DH_a/b.
DR InterPro; IPR036856; Ald_Oxase/Xan_DH_a/b_sf.
DR InterPro; IPR016208; Ald_Oxase/xanthine_DH-like.
DR InterPro; IPR005107; CO_DH_flav_C.
DR InterPro; IPR036683; CO_DH_flav_C_dom_sf.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR002346; Mopterin_DH_FAD-bd.
DR PANTHER; PTHR11908; XANTHINE DEHYDROGENASE; 1.
DR PANTHER; PTHR11908:SF100; XANTHINE DEHYDROGENASE; 1.
DR Pfam; PF01315; Ald_Xan_dh_C; 1.
DR Pfam; PF03450; CO_deh_flav_C; 1.
DR Pfam; PF00941; FAD_binding_5; 1.
DR SMART; SM01008; Ald_Xan_dh_C; 1.
DR SMART; SM01092; CO_deh_flav_C; 1.
DR SUPFAM; SSF55447; CO dehydrogenase flavoprotein C-terminal domain-like; 1.
DR SUPFAM; SSF54665; CO dehydrogenase molybdoprotein N-domain-like; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 13..202
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAN34744.1"
FT NON_TER 508
FT /evidence="ECO:0000313|EMBL:AAN34744.1"
SQ SEQUENCE 508 AA; 56262 MW; 5E4A2D71365EBAEC CRC64;
QLTTTYDSES LIFSSERVTW YRPTTLRELL QLKADHPTAK LVVGNTEVGV EVKFKHFLYP
HLINPTQVSE LLEVRESEES IYFGAAVNLM EIDALLRQRI EELPEAQTRL FQCTVDMLHY
FAGKQIRNVA CLGGNIMTGS PISDMNPVLT AASARLEVAS LVDGKTSHRT VHMGTGFFTG
YRRNVIEPHE VLLGIHFQKT TPDQHIVAFK QARRRDDDIA IVNAAVNVRF EPQTNVVAEI
SMAFGGMAPT TVLAPRTSQL MVKQPLNHQL IERVAESLCG ELPLAASAPG GMIAYRRALV
VSLFFKAYLS ISRRLSEAGI ISGDAIPPEE HSGAELFHTP TLRSAQLFER VCSEQPVCDP
IGRPELHAAA LKQATGEAIY TDDIPRMDGE VYLGFVLSTK PRAQITKLDA SEALALEGVH
AFFSHKDLTE HENEVGPVFH DEHVFAAGEV HCYGQIVGAV AADNKALAQR AARLVRVEYK
ELTPVIVTIE QAIEHGSYFP DYPRYVNK
//
