ID Q8ITL6_PLAFA Unreviewed; 272 AA.
AC Q8ITL6;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 22-FEB-2023, entry version 53.
DE SubName: Full=Merozoite surface protein 4 {ECO:0000313|EMBL:AAN07134.1};
GN Name=MSP4 {ECO:0000313|EMBL:AAN07134.1};
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:AAN07134.1};
RN [1] {ECO:0000313|EMBL:AAN07134.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12200485;
RA Jongwutiwes S., Putaporntip C., Friedman R., Hughes A.L.;
RT "The extent of nucleotide polymorphism is highly variable across a 3-kb
RT region on Plasmodium falciparum chromosome 2.";
RL Mol. Biol. Evol. 19:1585-1590(2002).
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DR EMBL; AF447572; AAN07134.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ITL6; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR Pfam; PF12947; EGF_3; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS01186; EGF_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:AAN07134.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REGION 50..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..200
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 30533 MW; 60F1F393B4AF8DAC CRC64;
MWIVKFLIVV HFFIICTINF DKLYISYSYN IVPENGRMLN MRILGEEKPN VNGVSTSDTP
GGNESSSASP NLSDAAEKKD EKEASEQGEE SHKKENSQES ANGKDDVKEE KKTNEKKDDG
KTDKVQEKVL EKSPKESQMV DDKKKTEAIP KKVVQPSSSN SGGHVGEEED HNEGEGEHEE
EEEHEEDDDV EDDDTYNKDD LEDEDLCKHN NGGCGDDKLC EYVGNRRVKC KCKEGYKLEG
IECVELLSLA SSSLNLIFNS FITIFVVILL IN
//
