ID GP115_HUMAN Reviewed; 695 AA.
AC Q8IZF3; B3KTD0; Q2PNZ0; Q5T5B5; Q5T5B6; Q86SN9; Q8IXE6;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-APR-2013, entry version 84.
DE RecName: Full=Probable G-protein coupled receptor 115;
DE AltName: Full=G-protein coupled receptor PGR18;
DE Flags: Precursor;
GN Name=GPR115; Synonyms=PGR18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASN-541.
RC TISSUE=Testis;
RA Bonner T.I., Kauffman D., Nagle J.W., Sloger M.;
RT "Complete coding sequence of GPR115.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-541.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-541.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-589.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [7]
RP IDENTIFICATION.
RX PubMed=12435584; DOI=10.1016/S0014-5793(02)03574-3;
RA Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.;
RT "Novel human G protein-coupled receptors with long N-terminals
RT containing GPS domains and Ser/Thr-rich regions.";
RL FEBS Lett. 531:407-414(2002).
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] LEU-674.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC LN-TM7 subfamily.
CC -!- SIMILARITY: Contains 1 GPS domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN46671.1; Type=Erroneous gene model prediction;
CC Sequence=BAC45257.1; Type=Erroneous gene model prediction;
CC Sequence=CAI15579.1; Type=Erroneous gene model prediction;
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DR EMBL; DQ315370; ABC41929.1; -; mRNA.
DR EMBL; AB065474; BAC45257.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK095395; BAG53042.1; -; mRNA.
DR EMBL; AL356421; CAI15579.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL356421; CAI15581.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX04321.1; -; Genomic_DNA.
DR EMBL; AY255556; AAO85068.1; -; mRNA.
DR EMBL; AY140957; AAN46671.1; ALT_SEQ; mRNA.
DR IPI; IPI00217512; -.
DR RefSeq; NP_722580.3; NM_153838.3.
DR UniGene; Hs.150131; -.
DR ProteinModelPortal; Q8IZF3; -.
DR PhosphoSite; Q8IZF3; -.
DR DMDM; 296439339; -.
DR PaxDb; Q8IZF3; -.
DR PRIDE; Q8IZF3; -.
DR DNASU; 221393; -.
DR Ensembl; ENST00000283303; ENSP00000283303; ENSG00000153294.
DR Ensembl; ENST00000327753; ENSP00000328319; ENSG00000153294.
DR Ensembl; ENST00000371220; ENSP00000360264; ENSG00000153294.
DR GeneID; 221393; -.
DR KEGG; hsa:221393; -.
DR UCSC; uc003oyz.1; human.
DR CTD; 221393; -.
DR GeneCards; GC06P047653; -.
DR HGNC; HGNC:19011; GPR115.
DR HPA; HPA007158; -.
DR neXtProt; NX_Q8IZF3; -.
DR PharmGKB; PA134954617; -.
DR eggNOG; NOG313007; -.
DR HOVERGEN; HBG051768; -.
DR KO; K08457; -.
DR ChiTaRS; GPR115; human.
DR GenomeRNAi; 221393; -.
DR NextBio; 91307; -.
DR Bgee; Q8IZF3; -.
DR CleanEx; HS_GPR115; -.
DR Genevestigator; Q8IZF3; -.
DR GermOnline; ENSG00000153294; Homo sapiens.
DR GO; GO:0016021; C:integral to membrane; TAS:GDB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G-protein coupled receptor activity; TAS:GDB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR008078; GPCR_2_Ig-hepta_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS_dom.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; FALSE_NEG.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; FALSE_NEG.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; FALSE_NEG.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; G-protein coupled receptor;
KW Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
KW Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1 21 Potential.
FT CHAIN 22 695 Probable G-protein coupled receptor 115.
FT /FTId=PRO_0000070336.
FT TOPO_DOM 22 406 Extracellular (Potential).
FT TRANSMEM 407 427 Helical; Name=1; (Potential).
FT TOPO_DOM 428 440 Cytoplasmic (Potential).
FT TRANSMEM 441 461 Helical; Name=2; (Potential).
FT TOPO_DOM 462 485 Extracellular (Potential).
FT TRANSMEM 486 506 Helical; Name=3; (Potential).
FT TOPO_DOM 507 515 Cytoplasmic (Potential).
FT TRANSMEM 516 536 Helical; Name=4; (Potential).
FT TOPO_DOM 537 561 Extracellular (Potential).
FT TRANSMEM 562 582 Helical; Name=5; (Potential).
FT TOPO_DOM 583 606 Cytoplasmic (Potential).
FT TRANSMEM 607 627 Helical; Name=6; (Potential).
FT TOPO_DOM 628 634 Extracellular (Potential).
FT TRANSMEM 635 655 Helical; Name=7; (Potential).
FT TOPO_DOM 656 695 Cytoplasmic (Potential).
FT DOMAIN 346 396 GPS.
FT CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 229 229 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 250 250 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 257 257 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 263 263 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 264 264 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 286 286 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 340 340 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 379 379 N-linked (GlcNAc...) (Potential).
FT VARIANT 507 507 R -> C (in dbSNP:rs12110938).
FT /FTId=VAR_055930.
FT VARIANT 541 541 K -> N (in dbSNP:rs9369738).
FT /FTId=VAR_024476.
FT VARIANT 674 674 S -> L (in a breast cancer sample;
FT somatic mutation).
FT /FTId=VAR_036224.
FT CONFLICT 491 491 M -> I (in Ref. 6; AAO85068).
FT CONFLICT 538 540 EPE -> GPV (in Ref. 6; AAO85068).
SQ SEQUENCE 695 AA; 77719 MW; B902221DD0804D0E CRC64;
MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE KCEGPCISSS
NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK DSTGASRLSV AAPSIPLHIL
DFRAPETIES VAQGIRKNCP FDYACITDMV KSSETTSGNI AFIVELLKNI STDLSDNVTR
EKMKSYSEVA NHILDTAAIS NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI
QTKGFHINHN TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA
ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV GWHSKKRRWD
EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV LDYITCIGLS VSILSLVLCL
IIEATVWSRV VVTEISYMRH VCIVNIAVSL LTANVWFIIG SHFNIKAQDY NMCVAVTFFS
HFFYLSLFFW MLFKALLIIY GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE
KGYMRPEACW LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII
MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL FGTIMDHKIR
DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG
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