ID   Q8J7G0_9HIV1            Unreviewed;       209 AA.
AC   Q8J7G0;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Retrotranscriptase {ECO:0000313|EMBL:AAM69341.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AAM69341.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAM69341.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAM69341.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=273-8 {ECO:0000313|EMBL:AAM69341.1};
RA   Vidal C., Arnedo M., Garcia F., Mestre G., Plana M., Cruceta A., Capon A.,
RA   Gallart T., Miro J.M., Pumarola T., Gatell J.M.;
RT   "Genotypic and phenotypic resistance patterns in early stage HIV patients
RT   failing initial therapy with stavudine, didanosine and nevirapine.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF517060; AAM69341.1; -; Genomic_RNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW   Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT   DOMAIN          7..197
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAM69341.1"
FT   NON_TER         209
FT                   /evidence="ECO:0000313|EMBL:AAM69341.1"
SQ   SEQUENCE   209 AA;  24505 MW;  9D39A92FACE916C2 CRC64;
     CTEMEKEGKI SKIGPENPYN TPVFAIKKKD STKWRKLVDF RELNKRTQDF WEVQLGIPHP
     AGLKKKKSVT VLDVGDAYFS VPLDKDFRKY TAFTIPSTNN ETPGTRYQYN VLPQGWKGSP
     AIFQSSMTKI LEPFRKQNPD IVIYQYMDDL YVGSDLEIGQ HRTKIEELRQ HLLRWGFTTP
     DKKHQKEPPF LWMGYELHPD KWTVQPIEL
//