ID Q8JER1_9HIV1 Unreviewed; 161 AA.
AC Q8JER1;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAM21675.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAM21675.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JMB-1 {ECO:0000313|EMBL:AAM21675.1};
RX PubMed=12351957; DOI=10.1097/00002030-200209270-00014;
RA Poveda E., Rodes B., Toro C., Martin-Carbonero L., Gonzalez-Lahoz J.,
RA Soriano V.;
RT "Evolution of the gp41 env region in HIV-infected patients receiving T-20,
RT a fusion inhibitor.";
RL AIDS 16:1959-1961(2002).
RN [2] {ECO:0000313|EMBL:AAM21675.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JMB-1 {ECO:0000313|EMBL:AAM21675.1};
RX PubMed=15258964; DOI=10.1002/jmv.20141;
RA Poveda E., Rodes B., Labernardiere J.L., Benito J.M., Toro C.,
RA Gonzalez-Lahoz J., Faudon J.L., Clavel F., Schapiro J., Soriano V.;
RT "Evolution of genotypic and phenotypic resistance to Enfuvirtide in HIV-
RT infected patients experiencing prolonged virologic failure.";
RL J. Med. Virol. 74:21-28(2004).
RN [3] {ECO:0000313|EMBL:AAM21675.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JMB-1 {ECO:0000313|EMBL:AAM21675.1};
RX PubMed=16286053; DOI=10.1016/j.jcv.2005.02.004;
RA Poveda E., Rodes B., Lebel-Binay S., Faudon J.L., Jimenez V., Soriano V.;
RT "Dynamics of enfuvirtide resistance in HIV-infected patients during and
RT after long-term enfuvirtide salvage therapy.";
RL J. Clin. Virol. 34:295-301(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AF500089; AAM21675.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AAM21675.1};
KW Virion {ECO:0000313|EMBL:AAM21675.1}.
FT DOMAIN 1..159
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAM21675.1"
FT NON_TER 161
FT /evidence="ECO:0000313|EMBL:AAM21675.1"
SQ SEQUENCE 161 AA; 18970 MW; 37C68ED2086147AE CRC64;
GAASLTLTVQ ARQLLSGIVQ QQNDLLRAIE AQQHMLQLTV WGIKQLQARV LAVERYLRDQ
QLLGIWGCSG KLICTTAVPW NSSWSNKSLN QIWDNMTWME WEREIDNYTG LIYDLLEKSQ
NQQEKNEQEL LELDKWANLW NWFDITQWLW YIKIFIMIVG G
//