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Database: UniProt
Entry: Q8JFE2_BOUMI
LinkDB: Q8JFE2_BOUMI
Original site: Q8JFE2_BOUMI 
ID   Q8JFE2_BOUMI            Unreviewed;       403 AA.
AC   Q8JFE2;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=Bmp4 protein {ECO:0000313|EMBL:BAC02591.1};
GN   Name=Bmp4 {ECO:0000313|EMBL:BAC02591.1};
OS   Boulengerochromis microlepis (Giant cichlid) (Tilapia microlepis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Boulengerochromini; Boulengerochromis.
OX   NCBI_TaxID=32488 {ECO:0000313|EMBL:BAC02591.1};
RN   [1] {ECO:0000313|EMBL:BAC02591.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12200490;
RA   Terai Y., Morikawa N., Okada N.;
RT   "The evolution of the pro-domain of bone morphogenetic protein 4 (Bmp4) in
RT   an explosively speciated lineage of East African cichlid fishes.";
RL   Mol. Biol. Evol. 19:1628-1632(2002).
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; AB084654; BAC02591.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8JFE2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PRINTS; PR00669; INHIBINA.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..403
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004310396"
FT   DOMAIN          287..403
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          279..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..300
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  46125 MW;  2DCFF6487CC7C619 CRC64;
     MIPGNRMLMV ILICQVLLGE SNHASLIPEE GKKKVPGLQG RSAAQSHELL RDFEATLLHM
     FGLKRRPRPS RSATVPRYLL DLYRLQSGEA EEAGAHDIAF EYPERSASRA NTVRGFHHEE
     HMEQLHELDD GGPMPIRFMF NLSSIPEDEL LSSAELRLYR HQIDEAIADA ISDDQALHRI
     NVYEVLKAPR PGQLITQLLD TRLVRHNASR WESFDVSPAV LRWTRERLPN YGLAVEVLHL
     NQTPRHQGRH VRISRSLHQE PGEDWEQLRP LLVTFGHDGK GHPLTRRTKR SPRQRGRKRN
     RNCRRHALYV DFSDVGWNDW IVAPPGYQAY YCHGECPFPL ADHLNSTNHA IVQTLVNSVN
     NNIPKACCVP TELSAISMLY LDEHDKVVLK NYQEMVVEGC GCR
//
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