ID Q8JFE2_BOUMI Unreviewed; 403 AA.
AC Q8JFE2;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Bmp4 protein {ECO:0000313|EMBL:BAC02591.1};
GN Name=Bmp4 {ECO:0000313|EMBL:BAC02591.1};
OS Boulengerochromis microlepis (Giant cichlid) (Tilapia microlepis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Boulengerochromini; Boulengerochromis.
OX NCBI_TaxID=32488 {ECO:0000313|EMBL:BAC02591.1};
RN [1] {ECO:0000313|EMBL:BAC02591.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12200490;
RA Terai Y., Morikawa N., Okada N.;
RT "The evolution of the pro-domain of bone morphogenetic protein 4 (Bmp4) in
RT an explosively speciated lineage of East African cichlid fishes.";
RL Mol. Biol. Evol. 19:1628-1632(2002).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AB084654; BAC02591.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8JFE2; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..403
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004310396"
FT DOMAIN 287..403
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 279..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..300
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 46125 MW; 2DCFF6487CC7C619 CRC64;
MIPGNRMLMV ILICQVLLGE SNHASLIPEE GKKKVPGLQG RSAAQSHELL RDFEATLLHM
FGLKRRPRPS RSATVPRYLL DLYRLQSGEA EEAGAHDIAF EYPERSASRA NTVRGFHHEE
HMEQLHELDD GGPMPIRFMF NLSSIPEDEL LSSAELRLYR HQIDEAIADA ISDDQALHRI
NVYEVLKAPR PGQLITQLLD TRLVRHNASR WESFDVSPAV LRWTRERLPN YGLAVEVLHL
NQTPRHQGRH VRISRSLHQE PGEDWEQLRP LLVTFGHDGK GHPLTRRTKR SPRQRGRKRN
RNCRRHALYV DFSDVGWNDW IVAPPGYQAY YCHGECPFPL ADHLNSTNHA IVQTLVNSVN
NNIPKACCVP TELSAISMLY LDEHDKVVLK NYQEMVVEGC GCR
//