ID Q8JGK1_GINCI Unreviewed; 118 AA.
AC Q8JGK1;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Antigen receptor {ECO:0000313|EMBL:AAM52962.1};
DE Flags: Fragment;
GN Name=NAR {ECO:0000313|EMBL:AAM52962.1};
OS Ginglymostoma cirratum (Nurse shark) (Squalus cirratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes;
OC Ginglymostomatidae; Ginglymostoma.
OX NCBI_TaxID=7801 {ECO:0000313|EMBL:AAM52962.1};
RN [1] {ECO:0000313|EMBL:AAM52962.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:AAM52962.1};
RX PubMed=12389098; DOI=10.1007/s00251-002-0479-z;
RA Diaz M., Stanfield R.L., Greenberg A.S., Flajnik M.F.;
RT "Structural analysis, selection, and ontogeny of the shark new antigen
RT receptor (IgNAR): identification of a new locus preferentially expressed in
RT early development.";
RL Immunogenetics 54:501-512(2002).
CC -!- SUBUNIT: Alpha-beta TR is a heterodimer composed of an alpha and beta
CC chain; disulfide-linked. The alpha-beta TR is associated with the
CC transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR
CC or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in
CC the endoplasmic reticulum where a single alpha-beta TR heterodimer
CC associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer
CC and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E
CC and CD3G-CD3E heterodimers preferentially associate with TR alpha and
CC TR beta chains, respectively. The association of the CD247 homodimer is
CC the last step of TcR assembly in the endoplasmic reticulum and is
CC required for transport to the cell surface.
CC {ECO:0000256|ARBA:ARBA00038651}.
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DR EMBL; AY114765; AAM52962.1; -; mRNA.
DR AlphaFoldDB; Q8JGK1; -.
DR CDD; cd00099; IgV; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR19343:SF13; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19343; T CELL RECEPTOR ALPHA VARIABLE 1-2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00043266};
KW Immunity {ECO:0000256|ARBA:ARBA00043266};
KW Receptor {ECO:0000313|EMBL:AAM52962.1};
KW T cell receptor {ECO:0000256|ARBA:ARBA00043266}.
FT DOMAIN 7..96
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAM52962.1"
FT NON_TER 118
FT /evidence="ECO:0000313|EMBL:AAM52962.1"
SQ SEQUENCE 118 AA; 13036 MW; 62C24FB715C71127 CRC64;
VLLALLPYVF TARVDQTPQT ITKETGESLT INCVLRDSNC ALSSTYWYRK KSGSTNEESI
SKGGRYVETV NSGSKSFSLR INDLTVEDSG TYRCNVYSWY GYDCAELDVY GGGTVVTV
//
