ID Q8JH38_OREMO Unreviewed; 380 AA.
AC Q8JH38;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 22-FEB-2023, entry version 72.
DE RecName: Full=creatine kinase {ECO:0000256|ARBA:ARBA00012231};
DE EC=2.7.3.2 {ECO:0000256|ARBA:ARBA00012231};
OS Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8127 {ECO:0000313|EMBL:AAK56448.1};
RN [1] {ECO:0000313|EMBL:AAK56448.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Gill {ECO:0000313|EMBL:AAK56448.1};
RA Gong H.Y., Huang W.T., Wu C.J., Chen M.H.C., Lin C.J.F., Wu J.L.,
RA Weng C.F.;
RT "Two Muscle-Type Creatine Kinase (CK) Isoforms Respond to Acute Salinity
RT Change in the Gill of Euryhaline Teleost (Oreochromis mossambicus).";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006798, ECO:0000256|PROSITE-ProRule:PRU00842,
CC ECO:0000256|RuleBase:RU000505}.
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DR EMBL; AY034098; AAK56448.1; -; mRNA.
DR AlphaFoldDB; Q8JH38; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004111; F:creatine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046314; P:phosphocreatine biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00716; creatine_kinase_like; 1.
DR Gene3D; 1.10.135.10; ATP:guanido phosphotransferase, N-terminal domain; 1.
DR Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 1.
DR InterPro; IPR000749; ATP-guanido_PTrfase.
DR InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR InterPro; IPR022413; ATP-guanido_PTrfase_N.
DR InterPro; IPR036802; ATP-guanido_PTrfase_N_sf.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR PANTHER; PTHR11547; ARGININE OR CREATINE KINASE; 1.
DR PANTHER; PTHR11547:SF60; CREATINE KINASE; 1.
DR Pfam; PF00217; ATP-gua_Ptrans; 1.
DR Pfam; PF02807; ATP-gua_PtransN; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR SUPFAM; SSF48034; Guanido kinase N-terminal domain; 1.
DR PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
DR PROSITE; PS51509; PHOSPHAGEN_KINASE_N; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00843};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PROSITE-
KW ProRule:PRU00843};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00843};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00843}.
FT DOMAIN 10..97
FT /note="Phosphagen kinase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51509"
FT DOMAIN 124..366
FT /note="Phosphagen kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51510"
FT BINDING 127..131
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843"
FT BINDING 190
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843"
FT BINDING 235
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843"
FT BINDING 291..295
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843"
FT BINDING 319..324
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843"
SQ SEQUENCE 380 AA; 42722 MW; 2B23C5CD342FB1D9 CRC64;
MTKNCHNDYK MKFSVDDEFP DLTKHNNHMA KVLTKEIYAK LRSKSTPSGF TVDDVTQTGV
DNPGHPFIMT GGCVAGDEES YEVFKDLLDP VISNRHGGYK PTDKHKTDLN FENLKGGDDL
DPNYVLSSRV RTGRSIKGFT LPPHNSRGER RAIQNLSIEA LSSLEGEFKG KYYPLDGMTD
AEQEQLIADH FLFDKPVSPL LTCAGMARDW PDARGIWHND NKTFLVWVNE EDHLRVISMQ
KGGNMKEVFR RFCVGLQKIE EIFKKHNHGF MWNEHLGYIL TCPSNLGTGL RGGVHVKLPK
LSTHPKFEEI LTRLRLQKRG TGGVDTASVG GVFDISNADR LGSFEVEQVQ LVVDGVKLMV
EMEKKLEKGE SIDGMIPAQK
//
