ID   Q8JJN8_HBV              Unreviewed;        94 AA.
AC   Q8JJN8;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
GN   Name=C {ECO:0000256|RuleBase:RU361253, ECO:0000313|EMBL:AAM53415.1};
GN   Synonyms=preC {ECO:0000313|EMBL:AAM53415.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AAM53415.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AAM53415.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Wong {ECO:0000313|EMBL:AAM53415.1};
RA   Weitzmann L., Kew M.C.;
RT   "Characterization of full-length HBV sequences from southern Africa.";
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC       acting as a T-cell tolerogen, by having an immunoregulatory effect
CC       which prevents destruction of infected cells by cytotoxic T-cells.
CC       {ECO:0000256|RuleBase:RU361253}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC   -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC       {ECO:0000256|RuleBase:RU361253}.
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DR   EMBL; U87747; AAM53415.1; -; Genomic_DNA.
DR   Proteomes; UP000159844; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR   InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR   InterPro; IPR002006; Hepatitis_core.
DR   InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR   Pfam; PF08290; Hep_core_N; 1.
DR   Pfam; PF00906; Hepatitis_core; 1.
DR   SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW   Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT   DOMAIN          1..29
FT                   /note="Hepatitis B virus capsid N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08290"
SQ   SEQUENCE   94 AA;  10431 MW;  2130511C016BD725 CRC64;
     MQLFSFHLCL IISCSCPTVQ ASKLCLGWLW GMDIDPYKEF GASVELLSFL PSDFFPAIRD
     LLRHRLCYVS GGLRVSGTLF TSPYGTQASY SVLG
//