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Database: UniProt
Entry: Q8JUE2_POVJC
LinkDB: Q8JUE2_POVJC
Original site: Q8JUE2_POVJC 
ID   Q8JUE2_POVJC            Unreviewed;       688 AA.
AC   Q8JUE2;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 105.
DE   RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805};
OS   JC polyomavirus (JCPyV) (JCV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Sepolyvirales; Polyomaviridae; Betapolyomavirus;
OC   Betapolyomavirus secuhominis.
OX   NCBI_TaxID=10632 {ECO:0000313|EMBL:AAM69543.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAM69543.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=#250E {ECO:0000313|EMBL:AAM69543.1};
RX   PubMed=12180767;
RA   Yanagihara R., Nerurkar V.R., Scheirich I., Agostini H.T., Mgone C.S.,
RA   Cui X., Jobes D.V., Cubitt C.L., Ryschkewitsch C.F., Hrdy D.B.,
RA   Friedlaender J.S., Stoner G.L.;
RT   "JC virus genotypes in the western Pacific suggest Asian mainland
RT   relationships and virus association with early population movements.";
RL   Hum. Biol. 74:473-488(2002).
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AF396422; AAM69543.1; -; Genomic_DNA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039576; P:disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039645; P:perturbation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 3.40.1310.20; -; 1.
DR   Gene3D; 1.10.287.110; DnaJ domain; 1.
DR   Gene3D; 1.20.1050.70; Large T antigen, SV40, domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.510; Zinc finger, large T-antigen D1 domain; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR016392; Lg_T_Ag_polyomavir.
DR   InterPro; IPR010932; Lg_T_Ag_Polyomavir_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003133; T_Ag_DNA-bd.
DR   InterPro; IPR017910; Znf_lg_T-Ag_D1-typ.
DR   InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf.
DR   Pfam; PF06431; Polyoma_lg_T_C; 1.
DR   Pfam; PF02217; T_Ag_DNA_bind; 1.
DR   PIRSF; PIRSF003368; Large_T_antigen_polyomaV; 1.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; Chaperone J-domain; 1.
DR   SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS51206; SF3_HELICASE_1; 1.
DR   PROSITE; PS51287; T_AG_OBD; 1.
DR   PROSITE; PS51341; ZF_LTAG_D1; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00620}; Early protein {ECO:0000256|ARBA:ARBA00022518};
KW   G1/S host cell cycle checkpoint dysregulation by virus
KW   {ECO:0000256|ARBA:ARBA00023309};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022632};
KW   Inhibition of host interferon signaling pathway by virus
KW   {ECO:0000256|ARBA:ARBA00022830};
KW   Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00671}.
FT   DOMAIN          12..75
FT                   /note="J"
FT                   /evidence="ECO:0000259|PROSITE:PS50076"
FT   DOMAIN          140..255
FT                   /note="T-ag OBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51287"
FT   DOMAIN          266..358
FT                   /note="T-ag D1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51341"
FT   DOMAIN          401..561
FT                   /note="SF3 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51206"
FT   DNA_BIND        140..255
FT                   /note="T-ag OBD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00620"
FT   REGION          115..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          632..656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        642..656
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  79320 MW;  4523BD0142A1915D CRC64;
     MDKVLNREES MELMDLLGLD RSAWGNIPVM RKAYLKKCKE LHPDKGGDED KMKRMNFLYK
     KMEQGVKVAH QPDFGTWNSS EVPTYGTDEW ESWWNTFNEK WDEDLFCHEE MFASDDQNTG
     SQHSTPPKKK KKVEDPKDFP VDLHAFLSQA VFSNRTVASF AVYTTKEKAQ ILYKKLMEKY
     SVTFISRHGF GSHNILFFLT PHRHRVSAIN NYCQKLCTFS FLICKGVNKE YLFYSALCRQ
     PYAVVEESIQ GGLKEHDFNP EEPEETKQVS WKLVTQYALD TKCEDVFLLM GMYLDFQENP
     LQCKKCEKKD QPNHFNHHEK HYYNAQIFAD SKNQKSICQQ AVDTVAAKQR VDSIHMTREE
     MLVERFNFLL DKMDLIFGAH GNAVLEQYMA GVAWIHCLLP QMDTVIYEFL KCIVLNIPKK
     RYWLFKGPID SGKTTLAAAL LDLCGGKSLN VNMPLERLNF ELGVGIDQFM VVFEDVKGTG
     AESRDLPSGH GISNLDCLRD YLDGSVKVNL ERKHQNKRTQ VFPPGIVTMN EYSVPRTLQA
     RFVRQIDFRP KAYLRKSLSC SEYLLEKRIL QSGMTLLLLL IWFRPVADFA AAIHERIVQW
     KERLDLEISM YTFSTMKANV GMGRPILDFP REEDSEAEDS GHGSSTESQS QCCSQVSEAS
     GADTQEHCTY HICKGFQCFK KPKTPPPK
//
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