ID K319L_MOUSE Reviewed; 1048 AA.
AC Q8K135; A2A790; Q3TTA3; Q8BHR5; Q8BHU7; Q8BHZ3; Q8VBZ9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 29-MAY-2013, entry version 83.
DE RecName: Full=Dyslexia-associated protein KIAA0319-like protein;
GN Name=Kiaa0319l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6, and NOD;
RC TISSUE=Brain, Cerebellum, Embryo, Embryonic heart, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-973 AND SER-977, AND
RP MASS SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
CC -!- FUNCTION: Possible role in axon guidance through interaction with
CC RTN4R (By similarity).
CC -!- SUBUNIT: Interacts with RTN4R (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule membrane; Multi-pass
CC membrane protein (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K135-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K135-2; Sequence=VSP_032956;
CC Note=No experimental confirmation available;
CC -!- PTM: N-glycosylated (By similarity).
CC -!- SIMILARITY: Contains 1 MANSC domain.
CC -!- SIMILARITY: Contains 5 PKD domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22154.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
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DR EMBL; AK043006; BAC31432.1; -; mRNA.
DR EMBL; AK049570; BAC33818.1; -; mRNA.
DR EMBL; AK084668; BAC39244.1; -; mRNA.
DR EMBL; AK147569; BAE27999.1; -; mRNA.
DR EMBL; AK161493; BAE36422.1; -; mRNA.
DR EMBL; AK170261; BAE41669.1; -; mRNA.
DR EMBL; AL606908; CAM19269.1; -; Genomic_DNA.
DR EMBL; AL606908; CAM19270.1; -; Genomic_DNA.
DR EMBL; BC022154; AAH22154.1; ALT_SEQ; mRNA.
DR EMBL; BC028869; AAH28869.1; -; mRNA.
DR IPI; IPI00453492; -.
DR IPI; IPI00626472; -.
DR RefSeq; NP_001030602.1; NM_001035525.1.
DR RefSeq; NP_001030603.1; NM_001035526.1.
DR RefSeq; NP_598647.1; NM_133886.2.
DR UniGene; Mm.206206; -.
DR ProteinModelPortal; Q8K135; -.
DR SMR; Q8K135; 295-399, 416-496, 504-594, 599-687.
DR PhosphoSite; Q8K135; -.
DR PaxDb; Q8K135; -.
DR PRIDE; Q8K135; -.
DR Ensembl; ENSMUST00000047431; ENSMUSP00000037802; ENSMUSG00000028830.
DR GeneID; 100317; -.
DR KEGG; mmu:100317; -.
DR UCSC; uc008utv.1; mouse.
DR UCSC; uc008utw.1; mouse.
DR MGI; MGI:2140475; AU040320.
DR eggNOG; COG3979; -.
DR GeneTree; ENSGT00390000006285; -.
DR HOVERGEN; HBG057130; -.
DR OrthoDB; EOG4B8JC7; -.
DR NextBio; 354386; -.
DR ArrayExpress; Q8K135; -.
DR Bgee; Q8K135; -.
DR Genevestigator; Q8K135; -.
DR GO; GO:0044433; C:cytoplasmic vesicle part; ISS:UniProtKB.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.670; -; 2.
DR InterPro; IPR003961; Fibronectin_type3.
DR InterPro; IPR013980; MANSC.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR000601; PKD_dom.
DR Pfam; PF02010; REJ; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00089; PKD; 5.
DR SUPFAM; SSF49299; PKD; 4.
DR PROSITE; PS50986; MANSC; 1.
DR PROSITE; PS50093; PKD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 1048 Dyslexia-associated protein KIAA0319-like
FT protein.
FT /FTId=PRO_0000329065.
FT TOPO_DOM 1 29 Cytoplasmic (Potential).
FT TRANSMEM 30 50 Helical; (Potential).
FT TOPO_DOM 51 928 Extracellular (Potential).
FT TRANSMEM 929 949 Helical; (Potential).
FT TOPO_DOM 950 1048 Cytoplasmic (Potential).
FT DOMAIN 49 127 MANSC.
FT DOMAIN 309 400 PKD 1.
FT DOMAIN 408 497 PKD 2.
FT DOMAIN 503 593 PKD 3.
FT DOMAIN 599 687 PKD 4.
FT DOMAIN 693 784 PKD 5.
FT MOD_RES 973 973 Phosphothreonine.
FT MOD_RES 977 977 Phosphoserine.
FT MOD_RES 1036 1036 Phosphothreonine (By similarity).
FT CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 394 394 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 1025 1048 YGQNGSVPNGQTPLKSRSAREEIL -> ALHWCRSQSLHHI
FT GWWCRAPVCHETSSTNSTPGSDSGFCKGGKNLSSDYRTRTK
FT SALVHGK (in isoform 2).
FT /FTId=VSP_032956.
FT CONFLICT 4 4 R -> G (in Ref. 1; BAC39244).
FT CONFLICT 579 579 Missing (in Ref. 1; BAE36422).
FT CONFLICT 656 656 G -> V (in Ref. 1; BAC33818).
FT CONFLICT 684 684 V -> A (in Ref. 1; BAC33818).
SQ SEQUENCE 1048 AA; 115312 MW; F4D51DD6DE4C889D CRC64;
MEKRLGVKPS PASWVLPGYC WQTSVKLPRS LYLLYSFFCF SVLWLSTDAD ESRCQQGKTL
YGAGLRTEGE NHLRLLAGSL PFHACRAACC RDSACHALWW LEGMCFQADC SKPQSCQPFR
TDSSNSMLII FQKSQTTDDL GLLPEDDEPH LLRLGWGRTS WRRQSLLGAP LTLSVPSSHH
QSLLRDRQKR DLSVVPTHGA MQHSKVNHSE EAGALSPTSA EVRKTITVAG SFTSNHTTQT
PEWPKNVSIH PEPSEHSSPV SGTPQVKSTE HSPTDAPLPV APSYSYATPT PQASSQSTSA
PHPVVKELVV SAGKSVQITL PKNEVQLNAF VLPEAEPGET YTYDWQLITH PTDYSGEVER
KHSQSLQLSK LTPGLYEFKV TVDGQNAHGE GYVNVTVKPE PRKNRPPVAV VSPQFQEISL
PTTSTIIDGS QSTDDDKIVQ YHWEELKGPL REEKISEDTA ILKLSKLVPG NYTFSLTVVD
SDGATNSTTA SLTVNKAVDY PPVANAGPNQ VITLPQNSIT LFGNQSTDDH GITSYEWSLS
PSSKGKVVEM QGVRTPALQL SAMQEGDYTY QLTVTDTAGQ QATAQVTVIV QPENNKPPQA
DAGPDKELTL PVDSTTLDGS KSTDDQRVVS YLWEQSRGPD GVQLENANSS VATVTGLQVG
TYVFTLTVKD ERNLQSQSSV NVIVKEEINK PPVAKIAGNV VVTLPTSTAE LDGSRSSDDK
GIVSYLWTRD ETSPAAGEVL NHSDHHPVLF LSNLVEGTYT FHLKVTDAKG ESDTDRTTVE
VKPDPRKSNL VEIILDVNVS QLTERLKGML IRQIGVLLGV LDSDIIVQKI QPYTEQSTKM
LFFVQNDPPH QLFKGHEVAA MLKSELQKQK ADFLIFRALE ISTVTCQLNC SDHGHCDSFT
KRCVCDPFWM ENFIKVQLRD GDSNCEWSVL YVIIASFVIV VALGILSWTT ICCCKRQKGK
PKRKSRYKIL DATDQESLEL KPTSRAGSKQ KGPTLSSSLM HSESELDSDD AIFTWPDREK
GKLLYGQNGS VPNGQTPLKS RSAREEIL
//
