ID GPR18_MOUSE Reviewed; 331 AA.
AC Q8K1Z6; Q3T9N3;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 01-MAY-2013, entry version 94.
DE RecName: Full=N-arachidonyl glycine receptor;
DE Short=NAGly receptor;
DE AltName: Full=G-protein coupled receptor 18;
GN Name=Gpr18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for N-arachidonyl glycine. The activity of this
CC receptor is mediated by G proteins which inhibit adenylyl cyclase.
CC May contribute to regulation of the immune system (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; AK156039; BAE33557.1; -; mRNA.
DR EMBL; AK156868; BAE33880.1; -; mRNA.
DR EMBL; AK157029; BAE33938.1; -; mRNA.
DR EMBL; AK172401; BAE42987.1; -; mRNA.
DR EMBL; BC034872; AAH34872.1; -; mRNA.
DR IPI; IPI00169867; -.
DR RefSeq; NP_877958.1; NM_182806.1.
DR UniGene; Mm.37405; -.
DR ProteinModelPortal; Q8K1Z6; -.
DR SMR; Q8K1Z6; 22-301.
DR PhosphoSite; Q8K1Z6; -.
DR PRIDE; Q8K1Z6; -.
DR Ensembl; ENSMUST00000055475; ENSMUSP00000061410; ENSMUSG00000050350.
DR GeneID; 110168; -.
DR KEGG; mmu:110168; -.
DR UCSC; uc007vap.1; mouse.
DR CTD; 2841; -.
DR MGI; MGI:107859; Gpr18.
DR eggNOG; NOG116115; -.
DR GeneTree; ENSGT00680000099997; -.
DR HOGENOM; HOG000112785; -.
DR HOVERGEN; HBG105013; -.
DR InParanoid; Q8K1Z6; -.
DR KO; K08410; -.
DR OMA; YAKGEWP; -.
DR OrthoDB; EOG47H5QJ; -.
DR NextBio; 363451; -.
DR Bgee; Q8K1Z6; -.
DR CleanEx; MM_GPR18; -.
DR Genevestigator; Q8K1Z6; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002286; P2_purnocptor.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01157; P2YPURNOCPTR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 331 N-arachidonyl glycine receptor.
FT /FTId=PRO_0000278174.
FT TOPO_DOM 1 26 Extracellular (Potential).
FT TRANSMEM 27 47 Helical; Name=1; (Potential).
FT TOPO_DOM 48 56 Cytoplasmic (Potential).
FT TRANSMEM 57 77 Helical; Name=2; (Potential).
FT TOPO_DOM 78 95 Extracellular (Potential).
FT TRANSMEM 96 116 Helical; Name=3; (Potential).
FT TOPO_DOM 117 138 Cytoplasmic (Potential).
FT TRANSMEM 139 159 Helical; Name=4; (Potential).
FT TOPO_DOM 160 191 Extracellular (Potential).
FT TRANSMEM 192 212 Helical; Name=5; (Potential).
FT TOPO_DOM 213 236 Cytoplasmic (Potential).
FT TRANSMEM 237 257 Helical; Name=6; (Potential).
FT TOPO_DOM 258 268 Extracellular (Potential).
FT TRANSMEM 269 289 Helical; Name=7; (Potential).
FT TOPO_DOM 290 331 Cytoplasmic (Potential).
FT CARBOHYD 14 14 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
FT DISULFID 94 172 By similarity.
FT CONFLICT 23 23 I -> V (in Ref. 1; BAE42987).
SQ SEQUENCE 331 AA; 37691 MW; 702FD55C911B4787 CRC64;
MATLSNHNQL DLSNGSHPEE YKIAALVFYS CIFLIGLFVN VTALWVFSCT TKKRTTVTIY
MMNVALLDLV FILSLPFRMF YYAKGEWPFG EYFCHILGAL VVFYPSLALW LLAFISADRY
MAIVQPKYAK ELKNTGKAVL ACGGVWVMTL TTTVPLLLLY EDPDKASSPA TCLKISDITH
LKAVNVLNFT RLIFFFLIPL FIMIGCYVVI IHSLLRGQTS KLKPKVKEKS IRIIMTLLLQ
VLVCFVPFHI CFAVLMLQGQ ENSYSPWGAF TTFLMNLSTC LDVVLYYIVS KQFQARVISV
MLYRNYLRSV RRKSVRSGSL RSLSNMNSEM L
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