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Database: UniProt
Entry: Q8K1Z6
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ID   GPR18_MOUSE             Reviewed;         331 AA.
AC   Q8K1Z6; Q3T9N3;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   01-OCT-2014, entry version 104.
DE   RecName: Full=N-arachidonyl glycine receptor;
DE            Short=NAGly receptor;
DE   AltName: Full=G-protein coupled receptor 18;
GN   Name=Gpr18 {ECO:0000312|EMBL:AAH34872.1, ECO:0000312|MGI:MGI:107859};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAE42987.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NOD {ECO:0000312|EMBL:BAE42987.1};
RC   TISSUE=Spleen {ECO:0000312|EMBL:BAE42987.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2] {ECO:0000312|EMBL:AAH34872.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH34872.1};
RC   TISSUE=Mammary gland {ECO:0000312|EMBL:AAH34872.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for N-arachidonyl glycine. The activity of this
CC       receptor is mediated by G proteins which inhibit adenylyl cyclase.
CC       May contribute to regulation of the immune system (By similarity).
CC       {ECO:0000250|UniProtKB:Q14330}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AK156039; BAE33557.1; -; mRNA.
DR   EMBL; AK156868; BAE33880.1; -; mRNA.
DR   EMBL; AK157029; BAE33938.1; -; mRNA.
DR   EMBL; AK172401; BAE42987.1; -; mRNA.
DR   EMBL; BC034872; AAH34872.1; -; mRNA.
DR   CCDS; CCDS27342.1; -.
DR   RefSeq; NP_877958.1; NM_182806.1.
DR   UniGene; Mm.37405; -.
DR   ProteinModelPortal; Q8K1Z6; -.
DR   SMR; Q8K1Z6; 22-301.
DR   GuidetoPHARMACOLOGY; 89; -.
DR   PhosphoSite; Q8K1Z6; -.
DR   PRIDE; Q8K1Z6; -.
DR   Ensembl; ENSMUST00000055475; ENSMUSP00000061410; ENSMUSG00000050350.
DR   GeneID; 110168; -.
DR   KEGG; mmu:110168; -.
DR   UCSC; uc007vap.1; mouse.
DR   CTD; 2841; -.
DR   MGI; MGI:107859; Gpr18.
DR   eggNOG; NOG116115; -.
DR   GeneTree; ENSGT00730000110768; -.
DR   HOGENOM; HOG000112785; -.
DR   HOVERGEN; HBG105013; -.
DR   InParanoid; Q8K1Z6; -.
DR   KO; K08410; -.
DR   OMA; YAKGEWP; -.
DR   OrthoDB; EOG7SBNP4; -.
DR   PhylomeDB; Q8K1Z6; -.
DR   TreeFam; TF330775; -.
DR   NextBio; 363451; -.
DR   PRO; PR:Q8K1Z6; -.
DR   Bgee; Q8K1Z6; -.
DR   CleanEx; MM_GPR18; -.
DR   Genevestigator; Q8K1Z6; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR028335; GPR18.
DR   PANTHER; PTHR24232:SF1; PTHR24232:SF1; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    331       N-arachidonyl glycine receptor.
FT                                /FTId=PRO_0000278174.
FT   TOPO_DOM      1     26       Extracellular. {ECO:0000255}.
FT   TRANSMEM     27     47       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     48     56       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     57     77       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     78     95       Extracellular. {ECO:0000255}.
FT   TRANSMEM     96    116       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    117    138       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    139    159       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    160    191       Extracellular. {ECO:0000255}.
FT   TRANSMEM    192    212       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    213    236       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    237    257       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    258    268       Extracellular. {ECO:0000255}.
FT   TRANSMEM    269    289       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    290    331       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     14     14       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     94    172       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   CONFLICT     23     23       I -> V (in Ref. 1; BAE42987).
FT                                {ECO:0000305}.
SQ   SEQUENCE   331 AA;  37691 MW;  702FD55C911B4787 CRC64;
     MATLSNHNQL DLSNGSHPEE YKIAALVFYS CIFLIGLFVN VTALWVFSCT TKKRTTVTIY
     MMNVALLDLV FILSLPFRMF YYAKGEWPFG EYFCHILGAL VVFYPSLALW LLAFISADRY
     MAIVQPKYAK ELKNTGKAVL ACGGVWVMTL TTTVPLLLLY EDPDKASSPA TCLKISDITH
     LKAVNVLNFT RLIFFFLIPL FIMIGCYVVI IHSLLRGQTS KLKPKVKEKS IRIIMTLLLQ
     VLVCFVPFHI CFAVLMLQGQ ENSYSPWGAF TTFLMNLSTC LDVVLYYIVS KQFQARVISV
     MLYRNYLRSV RRKSVRSGSL RSLSNMNSEM L
//
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