ID CLM2_MOUSE Reviewed; 196 AA.
AC Q8K249;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 01-MAY-2013, entry version 83.
DE RecName: Full=CMRF35-like molecule 2;
DE Short=CLM-2;
DE AltName: Full=CD300 antigen-like family member E;
DE AltName: CD_antigen=CD300e;
DE Flags: Precursor;
GN Name=Cd300e; Synonyms=Cd300le, Clm2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6;
RX PubMed=14662855;
RA Chung D.-H., Humphrey M.B., Nakamura M.C., Ginzinger D.G.,
RA Seaman W.E., Daws M.R.;
RT "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit
RT osteoclast formation.";
RL J. Immunol. 171:6541-6548(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Colonna M.;
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably acts as an activating receptor (By similarity).
CC -!- SUBUNIT: Interacts with TYROBP (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein (Potential).
CC -!- SIMILARITY: Belongs to the CD300 family.
CC -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like)
CC domain.
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DR EMBL; AY457048; AAR27939.1; -; mRNA.
DR EMBL; AF437879; AAN86136.1; -; mRNA.
DR EMBL; AL607025; CAM21180.1; -; Genomic_DNA.
DR EMBL; BC034097; AAH34097.1; -; mRNA.
DR EMBL; BC039971; AAH39971.1; -; mRNA.
DR IPI; IPI00169832; -.
DR RefSeq; NP_742047.1; NM_172050.2.
DR UniGene; Mm.222667; -.
DR HSSP; Q6SJQ7; 1ZOX.
DR ProteinModelPortal; Q8K249; -.
DR SMR; Q8K249; 23-131.
DR STRING; 10090.ENSMUSP00000054883; -.
DR PaxDb; Q8K249; -.
DR PRIDE; Q8K249; -.
DR Ensembl; ENSMUST00000062787; ENSMUSP00000054883; ENSMUSG00000048498.
DR GeneID; 217306; -.
DR KEGG; mmu:217306; -.
DR UCSC; uc007mgk.1; mouse.
DR CTD; 342510; -.
DR MGI; MGI:2387602; Cd300e.
DR eggNOG; NOG47389; -.
DR GeneTree; ENSGT00470000042273; -.
DR HOGENOM; HOG000231065; -.
DR HOVERGEN; HBG063279; -.
DR InParanoid; Q8K249; -.
DR KO; K06719; -.
DR OMA; FRLSSPH; -.
DR OrthoDB; EOG4VMFG6; -.
DR NextBio; 375741; -.
DR Bgee; Q8K249; -.
DR CleanEx; MM_CD300E; -.
DR Genevestigator; Q8K249; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR PROSITE; PS50835; IG_LIKE; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
KW Immunity; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1 17 Potential.
FT CHAIN 18 196 CMRF35-like molecule 2.
FT /FTId=PRO_0000320124.
FT TOPO_DOM 18 171 Extracellular (Potential).
FT TRANSMEM 172 192 Helical; (Potential).
FT TOPO_DOM 193 196 Cytoplasmic (Potential).
FT DOMAIN 18 122 Ig-like V-type.
FT CARBOHYD 84 84 N-linked (GlcNAc...) (Potential).
FT DISULFID 36 104 By similarity.
SQ SEQUENCE 196 AA; 21822 MW; E23888479CB556E8 CRC64;
MRLCAGLLLL CFQGCLSLTG PGSVSGYVGG SLRVQCQYSP SYKGYMKYWC RGPHDTTCKT
IVETDGSEKE KRSGPVSIRD HASNSTITVI MEDLSEDNAG SYWCKIQTSF IWDSWSRDPS
VSVRVNVFPA TTPTLPATTA ILPLVNSGQN LRISTNVMFI FQLWSLLSSI QFQVLVFLKL
PLFLSMLCAI FWVNRL
//
