ID Q8KC98_CHLTE Unreviewed; 1102 AA.
AC Q8KC98;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=Rab family protein {ECO:0000313|EMBL:AAM72753.1};
GN OrderedLocusNames=CT1526 {ECO:0000313|EMBL:AAM72753.1};
OS Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
OS (Chlorobium tepidum).
OC Bacteria; Chlorobiota; Chlorobiia; Chlorobiales; Chlorobiaceae;
OC Chlorobaculum.
OX NCBI_TaxID=194439 {ECO:0000313|EMBL:AAM72753.1, ECO:0000313|Proteomes:UP000001007};
RN [1] {ECO:0000313|EMBL:AAM72753.1, ECO:0000313|Proteomes:UP000001007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49652 / DSM 12025 / NBRC 103806 / TLS
RC {ECO:0000313|Proteomes:UP000001007};
RX PubMed=12093901; DOI=10.1073/pnas.132181499;
RA Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J.,
RA Deboy R., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D.,
RA Durkin A.S., Kolonay J.L., Yang F., Holt I., Umayam L.A., Mason T.,
RA Brenner M., Shea T.P., Parksey D., Nierman W.C., Feldblyum T.V.,
RA Hansen C.L., Craven M.B., Radune D., Vamathevan J., Khouri H., White O.,
RA Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A.,
RA Fraser C.M.;
RT "The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic,
RT anaerobic, green-sulfur bacterium.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
RN [2] {ECO:0007829|PDB:3DPT, ECO:0007829|PDB:3DPU}
RP X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 412-946.
RX PubMed=18650931; DOI=10.1038/emboj.2008.150;
RA Gotthardt K., Weyand M., Kortholt A., Van Haastert P.J., Wittinghofer A.;
RT "Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic
RT homologue of the human LRRK2 Parkinson kinase.";
RL EMBO J. 27:2239-2249(2008).
RN [3] {ECO:0007829|PDB:5IL7}
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-441.
RX PubMed=27357661; DOI=10.1073/pnas.1523708113;
RA Guaitoli G., Raimondi F., Gilsbach B.K., Gomez-Llorente Y., Deyaert E.,
RA Renzi F., Li X., Schaffner A., Jagtap P.K., Boldt K., von Zweydorf F.,
RA Gotthardt K., Lorimer D.D., Yue Z., Burgin A., Janjic N., Sattler M.,
RA Versees W., Ueffing M., Ubarretxena-Belandia I., Kortholt A.,
RA Gloeckner C.J.;
RT "Structural model of the dimeric Parkinson's protein LRRK2 reveals a
RT compact architecture involving distant interdomain contacts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:E4357-E4366(2016).
RN [4] {ECO:0007829|PDB:6HLU}
RP X-RAY CRYSTALLOGRAPHY (3.29 ANGSTROMS) OF 1-946.
RX PubMed=30538153; DOI=10.1042/BCJ20180803;
RA Deyaert E., Leemans M., Singh R.K., Gallardo R., Steyaert J., Kortholt A.,
RA Lauer J., Versees W.;
RT "Structure and nucleotide-induced conformational dynamics of the
RT <i>Chlorobium tepidum</i> Roco protein.";
RL Biochem. J. 476:51-66(2019).
CC -!- INTERACTION:
CC Q8KC98; Q8KC98: CT1526; NbExp=7; IntAct=EBI-8063154, EBI-8063154;
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DR EMBL; AE006470; AAM72753.1; -; Genomic_DNA.
DR RefSeq; NP_662411.1; NC_002932.3.
DR RefSeq; WP_010933192.1; NC_002932.3.
DR PDB; 3DPT; X-ray; 2.90 A; A/B=615-946.
DR PDB; 3DPU; X-ray; 2.90 A; A/B=412-946.
DR PDB; 5IL7; X-ray; 2.30 A; A/B=1-441.
DR PDB; 6HLU; X-ray; 3.29 A; A/B=1-946.
DR PDBsum; 3DPT; -.
DR PDBsum; 3DPU; -.
DR PDBsum; 5IL7; -.
DR PDBsum; 6HLU; -.
DR AlphaFoldDB; Q8KC98; -.
DR SASBDB; Q8KC98; -.
DR SMR; Q8KC98; -.
DR MINT; Q8KC98; -.
DR STRING; 194439.CT1526; -.
DR EnsemblBacteria; AAM72753; AAM72753; CT1526.
DR KEGG; cte:CT1526; -.
DR PATRIC; fig|194439.7.peg.1381; -.
DR eggNOG; COG1100; Bacteria.
DR eggNOG; COG4886; Bacteria.
DR HOGENOM; CLU_006878_2_0_10; -.
DR OrthoDB; 1148122at2; -.
DR EvolutionaryTrace; Q8KC98; -.
DR Proteomes; UP000001007; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR CDD; cd09914; RocCOR; 1.
DR Gene3D; 1.10.10.2200; -; 1.
DR Gene3D; 3.30.310.200; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR032171; COR.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF12799; LRR_4; 5.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00364; LRR_BAC; 11.
DR SMART; SM00368; LRR_RI; 6.
DR SMART; SM00365; LRR_SD22; 14.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00175; RAB; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 14.
DR PROSITE; PS51424; ROC; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3DPT, ECO:0007829|PDB:3DPU};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001007};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 446..620
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 1102 AA; 123777 MW; A8A3B242A43894A8 CRC64;
MSDLDVIRQI EQELGMQLEP VDKLKWYSKG YKLDKDQRVT AIGLYDCGSD TLDRIIQPLE
SLKSLSELSL SSNQITDISP LASLNSLSML WLDRNQITDI APLASLNSLS MLWLFGNKIS
DIAPLESLKS LTELQLSSNQ ITDIAPLASL KSLTELSLSG NNISDIAPLE SLKSLTELSL
SSNQITDIAP LASLKSLTEL SLSSNQISDI APLESLKSLT ELQLSRNQIS DIAPLESLKS
LTELQLSSNQ ITDIAPLASL KSLTELQLSR NQISDIAPLE SLNSLSKLWL NGNQITDIAP
LASLNSLTEL ELSSNQITDI APLASLKSLS TLWLSSNQIS DIAPLASLES LSELSLSSNQ
ISDISPLASL NSLTGFDVRR NPIKRLPETI TGFDMEILWN DFSSSGFITF FDNPLESPPP
EIVKQGKEAV RQYFQSIEEA RSKGEALVHL QEIKVHLIGD GMAGKTSLLK QLIGETFDPK
ESQTHGLNVV TKQAPNIKGL ENDDELKECL FHFWDFGGQE IMHASHQFFM TRSSVYMLLL
DSRTDSNKHY WLRHIEKYGG KSPVIVVMNK IDENPSYNIE QKKINERFPA IENRFHRISC
KNGDGVESIA KSLKSAVLHP DSIYGTPLAP SWIKVKEKLV EATTAQRYLN RTEVEKICND
SGITDPGERK TLLGYLNNLG IVLYFEALDL SEIYVLDPHW VTIGVYRIIN SSKTKNGHLN
TSALGYILNE EQIRCDEYDP AKNNKFTYTL LEQRYLLDIM KQFELCYDEG KGLFIIPSNL
PTQIDNEPEI TEGEPLRFIM KYDYLPSTII PRLMIAMQHQ ILDRMQWRYG MVLKSQDHEG
ALAKVVAETK DSTITIAIQG EPRCKREYLS IIWYEIKKIN ANFTNLDVKE FIPLPGHPDE
LVEYKELLGL EKMGRDEYVS GKLEKVFSVS KMLDSVISKE ERNKERLMGD INIKLENIGN
PTIPIHQQVE VNVSQETVQH VENLQGFFEN LKADILREAE LEIDDPKERK RLANELELAE
NAITKMDAAV KSGKNKLKPD VKDRLGEFID NLANENSRLR KGIALVMNGA EKVQKLARYY
NNVAPFFDLP SVPPVLLGKE KT
//
