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Database: UniProt
Entry: Q8KLT9_9NOCA
LinkDB: Q8KLT9_9NOCA
Original site: Q8KLT9_9NOCA 
ID   Q8KLT9_9NOCA            Unreviewed;       346 AA.
AC   Q8KLT9;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 125.
DE   RecName: Full=alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00013190};
DE            EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190};
GN   Name=sadh {ECO:0000313|EMBL:CAD36475.1};
GN   ORFNames=RHRU231_470141 {ECO:0000313|EMBL:CDZ89293.1};
OS   Rhodococcus ruber.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=1830 {ECO:0000313|EMBL:CAD36475.1};
RN   [1] {ECO:0000313|EMBL:CAD36475.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=219 {ECO:0000313|EMBL:CAD36475.1};
RA   Tamak C., Plattner H., Hummel W., Diekmann H., Meens J.;
RT   "Thermostable NAD+-dependent medium-chain alcohol dehydrogenase in
RT   tetrahydrofuran metabolism in Rhodococcus ruber strain 219.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-345 IN COMPLEX WITH NAD AND
RP   ZINC.
RX   PubMed=20676439; DOI=10.1039/c0cc00929f;
RA   Karabec M., Lyskowski A., Tauber K.C., Steinkellner G., Kroutil W.,
RA   Grogan G., Gruber K.;
RT   "Structural insights into substrate specificity and solvent tolerance in
RT   alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541.";
RL   Chem. Commun. (Camb.) 46:6314-6316(2010).
RN   [3] {ECO:0000313|EMBL:CDZ89293.1, ECO:0000313|Proteomes:UP000042997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ivshina I.B., Kuyukina M.S., Krivoruchko A.V., Barbe V., Fischer C.;
RT   "Draft Genome Sequence of Propane- and Butane-Oxidizing Actinobacterium
RT   Rhodococcus ruber IEGM 231.";
RL   Genome Announc. 2:1-2(2014).
RN   [4] {ECO:0000313|EMBL:CDZ89293.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Regsiter Alias;
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; AJ491307; CAD36475.1; -; Genomic_DNA.
DR   EMBL; CCSD01000058; CDZ89293.1; -; Genomic_DNA.
DR   RefSeq; WP_010594839.1; NZ_LRRL01000063.1.
DR   PDB; 2XAA; X-ray; 2.80 A; A/B/C/D=1-345.
DR   PDB; 3JV7; X-ray; 2.00 A; A/B/C/D=1-345.
DR   PDBsum; 2XAA; -.
DR   PDBsum; 3JV7; -.
DR   GeneID; 66836808; -.
DR   KEGG; rrz:CS378_07205; -.
DR   eggNOG; COG1064; Bacteria.
DR   OrthoDB; 3567264at2; -.
DR   BRENDA; 1.1.1.1; 4359.
DR   Proteomes; UP000042997; Unassembled WGS sequence.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd05284; arabinose_DH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR   PANTHER; PTHR42940:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7};
KW   Metal-binding {ECO:0000256|RuleBase:RU361277, ECO:0007829|PDB:2XAA};
KW   Nucleotide-binding {ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CAD36475.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000042997};
KW   Zinc {ECO:0000256|RuleBase:RU361277, ECO:0007829|PDB:2XAA}.
FT   DOMAIN          10..343
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         39
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         40
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         62
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         92
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         95
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         98
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         106
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         153
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         180
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA"
FT   BINDING         182
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         183
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         203
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         208
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         223
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         269
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         271
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         293
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         295
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
FT   BINDING         340
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0007829|PDB:2XAA, ECO:0007829|PDB:3JV7"
SQ   SEQUENCE   346 AA;  35449 MW;  F885D8B0F7E6C1CC CRC64;
     MKALQYTEIG SEPVVVDVPT PAPGPGEILL KVTAAGLCHS DIFVMDMPAE QYIYGLPLTL
     GHEGVGTVAE LGAGVTGFET GDAVAVYGPW GCGACHACAR GRENYCTRAA ELGITPPGLG
     SPGSMAEYMI VDSARHLVPI GDLDPVAAVP LTDAGLTPYH AISRVLPLLG PGSTAVVIGV
     GGLGHVGIQI LRAVSAARVI AVDLDDDRLA LAREVGADAA VKSGAGAADA IRELTGGEGA
     TAVFDFVGAQ STIDTAQQVV AIDGHISVVG IHAGAHAKVG FFMIPFGASV VTPYWGTRSE
     LMDVVDLARA GRLDIHTETF TLDEGPTAYR RLREGSIRGR GVVVPG
//
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