ID   Q8KRL2_ECOLX            Unreviewed;       937 AA.
AC   Q8KRL2;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Intimin {ECO:0000256|ARBA:ARBA00017346};
DE   AltName: Full=Attaching and effacing protein {ECO:0000256|ARBA:ARBA00029955};
OS   Escherichia coli.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562 {ECO:0000313|EMBL:AAN04013.1};
RN   [1] {ECO:0000313|EMBL:AAN04013.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14605134; DOI=10.1128/JCM.41.11.5022-5032.2003;
RA   Ramachandran V., Brett K., Hornitzky M.A., Dowton M., Bettelheim K.A.,
RA   Walker M.J., Djordjevic S.P.;
RT   "Distribution of intimin subtypes among Escherichia coli isolates from
RT   ruminant and human sources.";
RL   J. Clin. Microbiol. 41:5022-5032(2003).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000256|ARBA:ARBA00004203}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004203}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the intimin/invasin family.
CC       {ECO:0000256|ARBA:ARBA00010116}.
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DR   EMBL; AF530553; AAN04013.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8KRL2; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1080; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.40.160.160; Inverse autotransporter, beta-domain; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR003344; Big_1_dom.
DR   InterPro; IPR003343; Big_2.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR024519; IAT_beta.
DR   InterPro; IPR038177; IAT_beta_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003535; Intimin/invasin_bac.
DR   InterPro; IPR013117; Intimin_C.
DR   InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR   InterPro; IPR018392; LysM_dom.
DR   PANTHER; PTHR39576:SF2; ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED; 1.
DR   PANTHER; PTHR39576; ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED-RELATED; 1.
DR   Pfam; PF02369; Big_1; 2.
DR   Pfam; PF11924; IAT_beta; 1.
DR   Pfam; PF07979; Intimin_C; 1.
DR   Pfam; PF01476; LysM; 1.
DR   PRINTS; PR01369; INTIMIN.
DR   SMART; SM00634; BID_1; 2.
DR   SMART; SM00635; BID_2; 1.
DR   SMART; SM00257; LysM; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 3.
DR   PROSITE; PS51127; BIG1; 2.
DR   PROSITE; PS51782; LYSM; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          63..112
FT                   /note="LysM"
FT                   /evidence="ECO:0000259|PROSITE:PS51782"
FT   DOMAIN          560..653
FT                   /note="Big-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51127"
FT   DOMAIN          660..751
FT                   /note="Big-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51127"
SQ   SEQUENCE   937 AA;  102014 MW;  60B10D094F7DA513 CRC64;
     MITHGCYTRT RHKHKLKKTF VMLNAGLGLF FYVNQNSFAN GENYFKLSSD SKLLTQNAAQ
     NRLFYTLKTG ETVADLSKSQ NINLSTIWSL NKHLYSSESE MMKAAPGQQI ILPLKKLPVE
     YSALPHLGSA PVVAAGGVAG HTNKMAKMSP DMTKSNMTDD KALNYAAQQA ASLGSQLQSR
     SLNGDYAKDA ALGMAGNQAS SQLQAWLQHY GTAEVNLQSG NNFDGSSLDF LLPFYDTEEM
     LAFGQVGARY IDSRFTANLG AGQRFFLPEN MLGYNVFIDQ DFSGDNTRLG IGGEYWRDYF
     KSSVNGYFRM SGWHESYNKK DYDERPVNGF DIRFNGYLPS YPALGAKLMY EQYYGDNVAL
     FNADKLQSNP GAATVGVNYT PVPLVTMGVD YRHGTGNEND LLYSMQFRYQ FDKPWSQQIE
     PQYVNELRTL SGSRYDLVQR NNNIILEYKK QDILSLSIPH DINGTEHSTQ KIQLSVKSKY
     GLDRIVWDDS ALRSQGGQIQ HSGSQSAQDY QAILPAYVQG GSNIYKVTAR AYDRNGNSSN
     NVQLTITVLS NGQVVGQVGV TDFTADKTSA KADGTEAITY TATVKKNGVA QANVPVSFDI
     VSGVGKLGSE RVNTDNTGKA IVKLTSTIPG QVVISAKTAE MASAKNASAV IFIDQSQASI
     TEIKASKTTA KADGVDAILY TVKVMKNGVP EKGQVVAFST NLGKLNLQTV ETNKDGLASV
     TLTSVSVGKA VVSAKVSEAG SVINADAVNF FATLNIDKNV EIVGTKVSGE LPNIWLQYGQ
     VKLNANGGNG GYTWSSDNPN IASIDSNTGI ITLNKKGTAV IKVVSGDKQI ATYTIKTPQE
     IVSLDKNGKV TYDEANSICL GNSAHLSASV DTLKKVYSQW GPASKYEHYT QRTINAWIQQ
     TDKDKREGVA TTYDIVTNNM VQNVSSKTPN AYAVCVK
//