ID Q8LLX8_ORYSJ Unreviewed; 1825 AA.
AC Q8LLX8;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN OrderedLocusNames=LOC_Os10g17360 {ECO:0000313|EMBL:AAP52927.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947 {ECO:0000313|EMBL:AAP52927.1};
RN [1] {ECO:0000313|EMBL:AAP52927.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12791992; DOI=10.1126/science.1083523;
RG Rice Chromosome 10 Sequencing Consortium;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [2] {ECO:0000313|EMBL:AAP52927.1}
RP NUCLEOTIDE SEQUENCE.
RA Buell C.R., Wing R.A., McCombie W.R., Messing J., Yuan Q., Ouyang S.;
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAP52927.1}
RP NUCLEOTIDE SEQUENCE.
RA Buell R.;
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DP000086; AAP52927.1; -; Genomic_DNA.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR45835:SF87; RNA-DIRECTED DNA POLYMERASE; 1.
DR PANTHER; PTHR45835; YALI0A06105P; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF08284; RVP_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1825
FT /note="RNA-directed DNA polymerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010146457"
FT DOMAIN 662..677
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 912..1091
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1452..1619
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 327..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 216..243
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 327..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..361
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1825 AA; 207121 MW; 72F2AFDDF08AA92F CRC64;
MSWHRAGVLL LGAQSCLPVP GVPAVGGIGS VLLSMARMGW KLCHVFRLYT VVMAGSVTRR
GLGMTGFVLE LRGMCVALGY PHGVDYQARP LPEQEGDDAE PRAAWEVTAV ILAGSSERTS
LTVTAGGDSF PAACQSAALL AIGTLHQRYP DELQHSPYRY HPRRGGARDY ATFRDASSED
DATIVHLARM VEAYDAARID FHQMVRRGMV ENNMKILELR QENLQLKKDL DAVEAQLHQL
KIAQGEVCRP KRRRVCRSQK ITARKSTSRP ELVRQSLAWT CFVETPRAEP APVVPQEGEA
SGVGSTEALS VAGSVWGFQM VTTRRNAVTG DGNQPEGSNH NHQGNPPPPP PPPPPPPPDT
NAILTQILAQ QANMMTAFLH HLQNPPQHNA PPPPPQHSKL AEFLRIRPPT FSSSNNPVDA
LDWLHAVGKK LDTVQCSDEE KVIFAAHQLQ GPASLWWDHF QATQPEGQPI TWARFTAAFR
RTHVPAGVVA LKKREFRELK QGNRSVMEYL HEFNNLARYA PEDVREDEEK QEKFLAGMDP
ELSVRLVSGD YPDFQRLVDK SIRLEAKHKE LESHKRRLAN FRNQQGANQR VRYTNPYPGG
SSSQQQQQQQ QPRSAPRPQF VVRVPQPQQQ QGQQGTRAPR PPTPTVQPGQ GRRDAQGQQR
LCFNCFEPGH YADKCPKPRR QQGQAPPRSN NGGKDVIRGR VNHVTAKDVL TTPDVIVGTF
LVHSIPATIL FDSGASHSFI SVPFVGRNQL GVERLRNPLL ITTPGGVMTA KYYSPAVPIE
IQGIPFPSDL ILLDTKNLDV ILGMNWLAQF QGVVDCARRT VTLYRGPEQP VVFFVPPTSV
KSSELHQIGL SEIPIVREFG DVFPEELPGM PPKREIEFRI DLAPGTTPLH KRPYRMAANE
LTEVKKQLEE LKEKGYIRSS TSPWGAPVIF VEKKDKTKRM CVDYRALNEV TIKNKYPLPR
IDDLFDQLKG ATVFSKIDLH SGYHQLRIRE EDIPKTAFTT RYGLYEFTVM SFGLTNAPAF
FMNLMNKVFM EYLDKFVVVF IDDILIYSQS EEDHQHHLRL VLGKLREHQL YAKLSKREFW
LSEVKFLGHV ISAKGVAVDP ETVTAVTDWK QPKTVTQVRS FLGLAGYYRR FIENFSKIAR
PMTQLLKKEE KFVWSPQCEK AFQTLKEKLV SSPVLILPDT RKDFMVYCDA SRQGLGCVLM
QDGHVVAYAS RQLRPHEGNY PTHDLELAAV IHDLKIWRHY LIGNRCEIYT DHKSLKYIFT
QSDLNLRQRR WLELIKDYDV GIHYHPGKAN VVADALSRKS HCNTLNVRGI PPELNQQMEA
LNLSIVSRGF LAALEAKPTL LDQIREAQKN DPDMHGLLKN MKQGKAAGFT EEEHGTLWNG
NRVCVPDNRE LKQLILQEAH ESPYSIHPGS TKMYLDLKEK YWWVSMKREI AEFVALCDVC
QRVKAEHQRP AGLLQPLQVP EWKWDEIGMD FITGLPKTQG GYDSIWVVVD RLTKVARFIP
VKTTYGGNKL AELYFARIVS LHGVPKKIVS DRGSQFTSHF WKKLQEELGT RLNFSTAYHP
QTDGQTERLN QILEDMLRAC VLDFGKTWDK SLPYAEFSYN NSYQASIQMA PYEALYGRKC
RTPLLWDQVG ESQVFGTDIL REAEAKVRII RENLKVAQSR QKSYADNRRR DLEFAVDDFV
YLRVTPLRGV HRFQTKGKLA PRYVGPFRII ARRGEVAYQL ELPASLGNVH DVFHVSQLKK
CLRVPSEQAD SEQIEVREDL TYVERPVKIL DTMERRTRNR VIRFCKVQWS NHAEEEATWE
REDELKAAHP DLFASSSESR GRDSV
//
