GenomeNet

Database: UniProt
Entry: Q8LX30
LinkDB: Q8LX30
Original site: Q8LX30 
ID   COX1_LEMCA              Reviewed;         513 AA.
AC   Q8LX30;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   19-MAR-2014, entry version 63.
DE   RecName: Full=Cytochrome c oxidase subunit 1;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide I;
GN   Name=MT-CO1; Synonyms=COI, COXI, MTCO1;
OS   Lemur catta (Ring-tailed lemur).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lemuriformes; Lemuridae; Lemur.
OX   NCBI_TaxID=9447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12034869; DOI=10.1073/pnas.102164299;
RA   Arnason U., Adegoke J.A., Bodin K., Born E.W., Esa Y.B., Gullberg A.,
RA   Nilsson M., Short R.V., Xu X., Janke A.;
RT   "Mammalian mitogenomic relationships and the root of the eutherian
RT   tree.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:8151-8156(2002).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
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DR   EMBL; AJ421451; CAD13423.1; -; Genomic_DNA.
DR   RefSeq; NP_659290.1; NC_004025.1.
DR   ProteinModelPortal; Q8LX30; -.
DR   SMR; Q8LX30; 1-513.
DR   GeneID; 804958; -.
DR   CTD; 4512; -.
DR   HOVERGEN; HBG003841; -.
DR   ProtClustDB; MTH00103; -.
DR   UniPathway; UPA00705; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:1902600; P:hydrogen ion transmembrane transport; ISS:GOC.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.210.10; -; 1.
DR   InterPro; IPR000883; Cyt_c_Oxase_su1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR023616; Cyt_c_Oxase_su1_dom.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    513       Cytochrome c oxidase subunit 1.
FT                                /FTId=PRO_0000183351.
FT   TRANSMEM     17     37       Helical; (Potential).
FT   TRANSMEM     63     83       Helical; (Potential).
FT   TRANSMEM    102    122       Helical; (Potential).
FT   TRANSMEM    145    165       Helical; (Potential).
FT   TRANSMEM    183    203       Helical; (Potential).
FT   TRANSMEM    234    254       Helical; (Potential).
FT   TRANSMEM    268    288       Helical; (Potential).
FT   TRANSMEM    310    330       Helical; (Potential).
FT   TRANSMEM    338    358       Helical; (Potential).
FT   TRANSMEM    380    400       Helical; (Potential).
FT   TRANSMEM    416    436       Helical; (Potential).
FT   TRANSMEM    456    476       Helical; (Potential).
FT   METAL        61     61       Iron (heme A axial ligand) (Probable).
FT   METAL       240    240       Copper B (Probable).
FT   METAL       244    244       Copper B (Probable).
FT   METAL       290    290       Copper B (Probable).
FT   METAL       291    291       Copper B (Probable).
FT   METAL       376    376       Iron (heme A3 axial ligand) (Probable).
FT   METAL       378    378       Iron (heme A axial ligand) (Probable).
FT   CROSSLNK    240    244       1'-histidyl-3'-tyrosine (His-Tyr) (By
FT                                similarity).
SQ   SEQUENCE   513 AA;  56957 MW;  92BD547A0131E2F0 CRC64;
     MFINRWFYST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGSLLGD DQIYNVVVTA
     HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSFL LLLASSMVEA
     GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL HLAGVSSILG AINFITTVIN MKPPAMSQYQ
     TPLFVWSVMI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH
     PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD
     TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV GGLTGIVLAN
     SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF SGYTLDNTWA KIHFSIMFVG
     VNMTFFPQHF LGLSGMPRRY SDYPDAYTMW NTVSSIGSFI SLTAVMLMIF MIWEAFASKR
     EVLMVELTPT NLEWLHGCPP PYHTFEEPAY VKV
//
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