ID   Q8MQL3_DROVI            Unreviewed;       912 AA.
AC   Q8MQL3;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   22-FEB-2023, entry version 67.
DE   SubName: Full=Daughter of sevenless {ECO:0000313|EMBL:AAM97537.1};
GN   Name=dos {ECO:0000313|EMBL:AAM97537.1};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:AAM97537.1};
RN   [1] {ECO:0000313|EMBL:AAM97537.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12853137; DOI=10.1016/S0378-1119(03)00505-5;
RA   Abbeyquaye T., Riesgo-Escovar J., Raabe T., Thackeray J.R.;
RT   "Evolution of Gab family adaptor proteins.";
RL   Gene 311:43-50(2003).
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DR   EMBL; AY128671; AAM97537.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8MQL3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0042169; F:SH2 domain binding; IEA:EnsemblMetazoa.
DR   GO; GO:0042461; P:photoreceptor cell development; IEA:EnsemblMetazoa.
DR   GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:EnsemblMetazoa.
DR   GO; GO:0045500; P:sevenless signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0008293; P:torso signaling pathway; IEA:EnsemblMetazoa.
DR   CDD; cd13384; PH_Gab2_2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR046355; Gab1-4-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR   PANTHER; PTHR45960:SF2; PROTEIN DAUGHTER OF SEVENLESS; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          3..113
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          144..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          660..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          700..735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          764..792
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..433
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..734
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        767..792
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  98774 MW;  BD9D338D76A17DC3 CRC64;
     MDSTFHEGWL IKSPPSKRIW RARWRRRWFT LKQGEIPEQF CLEYYTDQYC RKLKGVIDLD
     QCEQVDCGLR LENRKQKFQY MFDIKTPKRT YYLAAETEAS MRDWVNCICQ VCHLHDTKQS
     NELPLGATAT STAAAAAAAA AAAADENRSA QQHTSSSGAL SNSTQNTTTT SLHSSAGTTA
     TNSLLRRPSV IDQQPQSANN NSDSVYVNTD YNNRETLLCD AHFDQQQLLS ACTATAPPSP
     ATALYLNQSA LIQAQAQAQA QAEQQQQAQA QAAAARLAIN ANGVVRKLPE HLVLNQQTLA
     EAMTQQQQHG SVQASPALST ASGPYIPISE CFTGSPKFLL DSHANAAAAL NNLDPKFYDT
     PRSHNNIGLN LTNDQSYSPK ITNCSLQQLA NASGKQRSQR SDSDSESVFT DDDEWAHPLP
     LRENVDRSTR PSDSSIENES FVLTYSQRFS KMPEDGAALP ATGTEKHAKQ LGTIAAAAAA
     ADGAGEHHTL KKLAKVLKNK NNLILDFKDN EKLQRDLPQL SDTENTSPAI VASRHANSSL
     IEESYDIPRS HQLPYCNVGQ LLGERPVTSP HNSNPIAAST PNLMADACAA AAPANPSQMA
     SSTAATTAPV NSPTSARTLP RQHCYTNAAP TRMEGNVFRY DFIEQADCPP VNRKLKPKVA
     NLPLEPTHKS SVEDKPPEEF PAKPPVAAME QLNSKLSATK LQSSAPPSVD RKCKPNAYKL
     GSSATMSPAT RRSTGAPLSM VLPHETDVHS PAAIAYFHET RTLPRQQHRQ HPNSPGSQSV
     QHQRTASAAA AMTSTAAAAA AAAAAHKQSQ QAVQQQQQQS EHKLQYFDLD VTNKPPLLNR
     QSMSVGNLYA QGGAGLGGVR LGATDAAAVR APVQSSVVYN FVDFVKTEAF KRIREERNKE
     SSESGGAGGG NK
//