ID Q8MQV4_DROME Unreviewed; 403 AA.
AC Q8MQV4;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 126.
DE SubName: Full=SD25933p {ECO:0000313|EMBL:AAM52781.1};
GN Name=sima {ECO:0000313|EMBL:AAM52781.1,
GN ECO:0000313|FlyBase:FBgn0266411};
GN ORFNames=CG45051 {ECO:0000313|FlyBase:FBgn0266411};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM52781.1};
RN [1] {ECO:0000313|EMBL:AAM52781.1}
RP NUCLEOTIDE SEQUENCE.
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AY122269; AAM52781.1; -; mRNA.
DR AlphaFoldDB; Q8MQV4; -.
DR AGR; FB:FBgn0266411; -.
DR FlyBase; FBgn0266411; sima.
DR VEuPathDB; VectorBase:FBgn0266411; -.
DR HOGENOM; CLU_010044_6_0_1; -.
DR ChiTaRS; sima; fly.
DR ExpressionAtlas; Q8MQV4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd11433; bHLH-PAS_HIF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF17; PROTEIN SIMILAR; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 2: Evidence at transcript level;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 72..125
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 167..240
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 44828 MW; 99BD5CA92F436741 CRC64;
MVSLIDTIEA AAEKQKQSQA VVTNTSASSS SCSSSFSASP PSSSVGSPSP GAPKTNLTAS
GKPKEKRRNN EKRKEKSRDA ARCRRSKETE IFMELSAALP LKTDDVNQLD KASVMRITIA
FLKIREMLQF VPSLRDCNDD IKQDIETAED QQEVKPKLEV GTEDWLNGAE ARELLKQTMD
GFLLVLSHEG DITYVSENVV EYLGITKIDT LGQQIWEYSH QCDHAEIKEA LSLKRELAQK
VKDEPQQNSG VSTHHRDLFV RLKCTLTSRG RSINIKSASY KVIHITGHLV VNAKGERLLM
AIGRPIPHPS NIEIPLGTST FLTKHSLDMR FTYVDDKMHD LLGYSPKDLL DTSLFSCQHG
ADSERLMATF KSDLVMLKGY HDCSSMKWIK AISGMPSKIA GRC
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