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Database: UniProt
Entry: Q8MXH5_CAEEL
LinkDB: Q8MXH5_CAEEL
Original site: Q8MXH5_CAEEL 
ID   Q8MXH5_CAEEL            Unreviewed;      1801 AA.
AC   Q8MXH5;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 2.
DT   30-AUG-2017, entry version 125.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCD64245.2};
GN   Name=unc-77 {ECO:0000313|EMBL:CCD64245.2,
GN   ECO:0000313|WormBase:C11D2.6c};
GN   ORFNames=C11D2.6 {ECO:0000313|WormBase:C11D2.6c}, CELE_C11D2.6
GN   {ECO:0000313|EMBL:CCD64245.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD64245.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD64245.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD64245.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284604; CCD64245.2; -; Genomic_DNA.
DR   PIR; T32962; T32962.
DR   RefSeq; NP_741414.2; NM_171353.4.
DR   UniGene; Cel.17060; -.
DR   PaxDb; Q8MXH5; -.
DR   EnsemblMetazoa; C11D2.6c; C11D2.6c; WBGene00006809.
DR   GeneID; 177379; -.
DR   UCSC; C11D2.6d; c. elegans.
DR   CTD; 177379; -.
DR   WormBase; C11D2.6c; CE48978; WBGene00006809; unc-77.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   HOGENOM; HOG000012967; -.
DR   InParanoid; Q8MXH5; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006809; -.
DR   ExpressionAtlas; Q8MXH5; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IDA:WormBase.
DR   GO; GO:0040017; P:positive regulation of locomotion; IGI:WormBase.
DR   GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IGI:WormBase.
DR   GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IGI:WormBase.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     92    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    169    189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    369    392       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    404    428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    562    586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    864    889       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    909    932       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    944    961       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1006   1028       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1120   1146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1201   1221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1233   1253       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1273   1291       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1307   1324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1345   1369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1430   1448       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    316       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      369    591       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      870   1150       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1200   1467       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      789    812       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1801 AA;  208832 MW;  1E241F7AD10DF772 CRC64;
     MLSSQHKKPV RSSYVESDRV EWALKIACTI SMITVCIHTP RTIELFQPLN YIILAADFIS
     VSIFMLDSVL RIHYEGIFRC DSSYLSNRWS QFSVFISIIH LLSFLLHCYQ LIDNFFPFLH
     LNYRAWYGAI RSIRPFIIIR LIPLVVKFKL PKNRIEQLLK RSSQQVKNVT LFFVFFMTLY
     AIFGIQLFGR MDYHCVQPKT DPNNVTIMDL AIPDTMCAPE GIGGYECPAP MVCMQLNLNA
     KGEGFYGMFN DFGASVFTVY LAASEEGWVY VLYDCMDSLP SYLAFLYFCT LIFFLAWLVK
     NVFIAVITET FAEIRVQFSE MWQKKEVTLD EGFRKKLEKT DDGWRLIRLD GEVEPEGPKQ
     KLQWMLRSMY FQCFVIIFVV INAIGNAMFV YRHDETDKPR KYNFYLFEVG FTILFNVECI
     IKILCYGFRN FIRRGIFKFE LILCLGSSLN CVKFFYERNY FTYFQTFRLL RLIKASPILE
     DFVWKIFSPG KKLGGLVIFT IAFICCYSAI SLQLFYSVPN LHHFRTFPQA FMSMFQIITQ
     EGWTDFVVEV LRATDDNLVP LVALYFVAYH LFVTLIVLSL FVAVILDNLE MDEELKKVKQ
     LRAREATTSM RSTLPWRLRV FEKFPTRPQM AAMRKADSDF PMPKVRGSFT HQFAVDHSLE
     TTDVIESDFE FPKRIMKSAG KRKISKSGLT FRQIGSTSLR CSLNNLLEMS DRTRQSLSNS
     LSFLPHFTRS SGSLYPRKDA LPKSRSMTGK FLQTAVRNKQ FNMYSENGDL SRPSDSAPKK
     NAKQGEIDIR ALQQKRQLAE ITRNRIEEDM RENHPFFDRP LFLVGRASQL REFCKKMVHS
     KYDSQDDGTN GGAKTKKRFK EIRALIGIMP YIDWAMATVT IVSCISMLFE SPWPTTGENL
     VMNNGYLQIS DYFFVLSMTF ELCVKIIANG LFFTPKAVVR DVGGVMNLFI YFTSVIFLAW
     MPKHVEINSL AQFLMICRAM RPLRIYTLVP HIRRVVLEFF RGFKEILLVT ILMIVVMFIF
     ASFGVQIVGG KLAACNDPTV SSRENCTGVF WQKLFVTRLE VYGKDTEAMH PKIMVPRVWT
     NPRNFNFDHV GNAMLALFET LSFKGWNVIR DILWSRHGPW AVVFIHIYVF IGCMIGLTLF
     VGVVIANYTQ NRGTALLTVD QRRWHDLKAR LKMAQPLHVP PKPSESARLR TKLYDLTMSR
     WFNQAFALLV VLNSFTLVIP WNVEEEEQRA TYVFTVTALA AFMNMLFVIE IILKVIAYTF
     SGFWQSRRNR VDLLITVFGV IWIFLHFFVA LPSSKIDVDV QVELKKFTYT FGYLVVILRF
     FTIASRNSTL KMLMLTVIMS MFRSFFIITA LFLLVLFYAY TGVILFPMVK YGMAVSKHVN
     FRTASEALVV LFRCLTGEDW NDIMHDCMRS APFCYWNEGM NYWETDCGNF YGAIIYFCSF
     YLIITYIVRN LLVAVIMENF SLFYSSEEDA LLSYADIRNF QYVWNMVDQE QKRTIPVERV
     KFLLRLLKGR LEVDPEKDRI LFKHMCYEME RLHNGEEVSF HDVLYMLSYR SVDIRKSLQL
     EELLQREELE FIIEEEVAKQ TIRTWLEGCL RKMRNPSQKD AEGVLPFGGG HPVIHSSGHS
     SISHEETVAQ RLRFENIRGD SVDTEETESS EEETPPPIRK KAAVKNRRGS IPDVLSRTGL
     FQEAARKFMV GSSSEKKQVK SRSPETVQLL PKRANSEIRK GSGQPKNFHL QLNVYDLPDV
     EERGEDSPFS PKNLSDDFNG EHSPLVITPS LPVPPTHGSP RPLMPCETTK DIEKWWNSLV
     D
//
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