ID Q8N081_9MUSC Unreviewed; 96 AA.
AC Q8N081;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00016352, ECO:0000256|RuleBase:RU000364};
DE EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190, ECO:0000256|RuleBase:RU000364};
DE Flags: Fragment;
GN Name=Adh {ECO:0000313|EMBL:AAM28710.1,
GN ECO:0000313|FlyBase:FBgn0044228};
OS Drosophila quadraria.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=67532 {ECO:0000313|EMBL:AAM28710.1};
RN [1] {ECO:0000313|EMBL:AAM28710.1}
RP NUCLEOTIDE SEQUENCE.
RX AGRICOLA=IND23292123;
RA Schawaroch V.A.;
RT "Phylogeny of a paradigm lineage: the Drosophila melanogaster species group
RT (Diptera: Drosophilidae).";
RL Biol. J. Linn. Soc. Lond. 76:21-37(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000256|RuleBase:RU000364};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000781,
CC ECO:0000256|RuleBase:RU000364};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC ECO:0000256|RuleBase:RU000364}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; AF459773; AAM28710.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8N081; -.
DR FlyBase; FBgn0044228; Dqua\Adh.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002425; ADH_Drosophila-type.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR42901; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR42901:SF1; ALCOHOL DEHYDROGENASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR01168; ALCDHDRGNASE.
DR PRINTS; PR01167; INSADHFAMILY.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|RuleBase:RU000364}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAM28710.1"
FT NON_TER 96
FT /evidence="ECO:0000313|EMBL:AAM28710.1"
SQ SEQUENCE 96 AA; 10458 MW; 3E4DF708E3564194 CRC64;
LKAINPKVTV TFYPYDVTVK IAETTKLLKT IFAKLKTVDI LINGAGILDD HEIERTIAVN
YTGLVNTTTA IMDFWDKRKG GPGGIICNIG SVTGFN
//
