ID OSR2_HUMAN Reviewed; 312 AA.
AC Q8N2R0; A8K626; Q96AM6; Q96LB6; Q96LB7;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 01-MAY-2013, entry version 93.
DE RecName: Full=Protein odd-skipped-related 2;
GN Name=OSR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Jiang R., Cho E.-S., Lan Y.;
RT "Isolation of the human OSR2 gene.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo, and Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=OSR2A;
CC IsoId=Q8N2R0-1; Sequence=Displayed;
CC Name=2; Synonyms=OSR2B;
CC IsoId=Q8N2R0-2; Sequence=VSP_017121;
CC -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
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DR EMBL; AY038072; AAK74066.1; -; mRNA.
DR EMBL; AY038073; AAK74067.1; -; mRNA.
DR EMBL; AK074518; BAC11035.1; -; mRNA.
DR EMBL; AK291491; BAF84180.1; -; mRNA.
DR EMBL; CH471060; EAW91785.1; -; Genomic_DNA.
DR EMBL; BC016936; AAH16936.1; -; mRNA.
DR IPI; IPI00719002; -.
DR IPI; IPI00943317; -.
DR RefSeq; NP_001135934.1; NM_001142462.1.
DR RefSeq; NP_443727.2; NM_053001.2.
DR UniGene; Hs.253247; -.
DR ProteinModelPortal; Q8N2R0; -.
DR IntAct; Q8N2R0; 1.
DR STRING; 9606.ENSP00000297565; -.
DR DMDM; 146345473; -.
DR PaxDb; Q8N2R0; -.
DR PRIDE; Q8N2R0; -.
DR Ensembl; ENST00000297565; ENSP00000297565; ENSG00000164920.
DR Ensembl; ENST00000435298; ENSP00000402862; ENSG00000164920.
DR Ensembl; ENST00000522510; ENSP00000430780; ENSG00000164920.
DR GeneID; 116039; -.
DR KEGG; hsa:116039; -.
DR UCSC; uc003yiq.3; human.
DR UCSC; uc003yir.3; human.
DR CTD; 116039; -.
DR GeneCards; GC08P099956; -.
DR HGNC; HGNC:15830; OSR2.
DR HPA; HPA052425; -.
DR MIM; 611297; gene.
DR neXtProt; NX_Q8N2R0; -.
DR PharmGKB; PA134924513; -.
DR eggNOG; COG5048; -.
DR HOGENOM; HOG000013107; -.
DR HOVERGEN; HBG054398; -.
DR InParanoid; Q8N2R0; -.
DR KO; K09215; -.
DR OrthoDB; EOG46MBJW; -.
DR PhylomeDB; Q8N2R0; -.
DR ChiTaRS; OSR2; human.
DR GenomeRNAi; 116039; -.
DR NextBio; 79729; -.
DR ArrayExpress; Q8N2R0; -.
DR Bgee; Q8N2R0; -.
DR CleanEx; HS_OSR2; -.
DR Genevestigator; Q8N2R0; -.
DR GermOnline; ENSG00000164920; Homo sapiens.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0060349; P:bone morphogenesis; ISS:UniProtKB.
DR GO; GO:0002062; P:chondrocyte differentiation; ISS:BHF-UCL.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISS:BHF-UCL.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISS:BHF-UCL.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISS:BHF-UCL.
DR GO; GO:0036023; P:embryonic skeletal limb joint morphogenesis; ISS:BHF-UCL.
DR GO; GO:0061029; P:eyelid development in camera-type eye; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; ISS:BHF-UCL.
DR GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
DR GO; GO:0001656; P:metanephros development; ISS:UniProtKB.
DR GO; GO:0042474; P:middle ear morphogenesis; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
DR GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
DR GO; GO:0033687; P:osteoblast proliferation; ISS:UniProtKB.
DR GO; GO:0060021; P:palate development; ISS:UniProtKB.
DR GO; GO:0030501; P:positive regulation of bone mineralization; ISS:BHF-UCL.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; IEA:Compara.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
DR GO; GO:0048793; P:pronephros development; IEA:Compara.
DR Gene3D; 3.30.160.60; -; 5.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1 312 Protein odd-skipped-related 2.
FT /FTId=PRO_0000047007.
FT ZN_FING 172 194 C2H2-type 1.
FT ZN_FING 200 222 C2H2-type 2.
FT ZN_FING 228 250 C2H2-type 3.
FT ZN_FING 256 278 C2H2-type 4.
FT ZN_FING 284 306 C2H2-type 5; degenerate.
FT VAR_SEQ 253 312 ESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVF
FT RRNCDLRRHSLTHTPRQDF -> TSSPTAASSAAKCSGETV
FT ICGGTA (in isoform 2).
FT /FTId=VSP_017121.
FT CONFLICT 132 132 K -> G (in Ref. 1; AAK74066).
FT CONFLICT 286 286 C -> R (in Ref. 2; BAC11035).
SQ SEQUENCE 312 AA; 35513 MW; 312E5A688EFB88B6 CRC64;
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH MNHWTLGYPN
VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG AIAHVLPALH KDRPRFDFAN
LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH
FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS
RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
RHSLTHTPRQ DF
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