ID Q8NHE6_CRIGR Unreviewed; 181 AA.
AC Q8NHE6;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=AID {ECO:0000313|EMBL:AAM95443.1};
DE Flags: Fragment;
GN Name=AID {ECO:0000313|EMBL:AAM95443.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:AAM95443.1};
RN [1] {ECO:0000313|EMBL:AAM95443.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12202747; DOI=10.1073/pnas.192442899;
RA Martin A., Scharff M.D.;
RT "Somatic hypermutation of the AID transgene in B and non-B cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:12304-12308(2002).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC family. {ECO:0000256|ARBA:ARBA00006576}.
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DR EMBL; AF529856; AAM95443.1; -; mRNA.
DR AlphaFoldDB; Q8NHE6; -.
DR GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01283; cytidine_deaminase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR InterPro; IPR013158; APOBEC_N.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR PANTHER; PTHR13857; MRNA EDITING ENZYME; 1.
DR PANTHER; PTHR13857:SF10; SINGLE-STRANDED DNA CYTOSINE DEAMINASE; 1.
DR Pfam; PF08210; APOBEC_N; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..112
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAM95443.1"
SQ SEQUENCE 181 AA; 21883 MW; A1972547BEA8E7D8 CRC64;
VRWAKGRRET YLCYVVKRRD SATSFSLDFG YLRNKNGCHV ELLFLRYISD WDLDPGRCYR
VTWFTSWSPC YDCARHVADF LRGNPNLSLR IFTARLYFCE DRKAEPEGLR RLHRAGVQIA
IMTFKDYFYC WNTFVENHER TFKAWEGLHE NSVRLSRQLR RIILPLYEVD DLRDAFRTWG
R
//
