ID   Q8NIP0_CRYNE            Unreviewed;       431 AA.
AC   Q8NIP0;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=glucan 1,3-beta-glucosidase {ECO:0000256|ARBA:ARBA00038929};
DE            EC=3.2.1.58 {ECO:0000256|ARBA:ARBA00038929};
GN   Name=celc {ECO:0000313|EMBL:CAD31110.1};
OS   Cryptococcus neoformans (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=5207 {ECO:0000313|EMBL:CAD31110.1};
RN   [1] {ECO:0000313|EMBL:CAD31110.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=309 Cap67 {ECO:0000313|EMBL:CAD31110.1};
RA   Biondo C., Beninati C., Bombaci M., Mancuso G., Midiri A., Messina L.,
RA   Teti G.;
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Successive hydrolysis of beta-D-glucose units from the non-
CC         reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.;
CC         EC=3.2.1.58; Evidence={ECO:0000256|ARBA:ARBA00036824};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
CC       {ECO:0000256|ARBA:ARBA00005641, ECO:0000256|RuleBase:RU361153}.
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DR   EMBL; AJ486863; CAD31110.1; -; mRNA.
DR   AlphaFoldDB; Q8NIP0; -.
DR   CAZy; GH5; Glycoside Hydrolase Family 5.
DR   VEuPathDB; FungiDB:CKF44_02225; -.
DR   VEuPathDB; FungiDB:CNAG_02225; -.
DR   VEuPathDB; FungiDB:CNBE3160; -.
DR   VEuPathDB; FungiDB:CNE03150; -.
DR   VEuPathDB; FungiDB:LQV05_005230; -.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR001547; Glyco_hydro_5.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR31297:SF1; GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED; 1.
DR   PANTHER; PTHR31297; GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B; 1.
DR   Pfam; PF00150; Cellulase; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   2: Evidence at transcript level;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361153};
KW   Hydrolase {ECO:0000256|RuleBase:RU361153};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..431
FT                   /note="glucan 1,3-beta-glucosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012587739"
FT   DOMAIN          83..285
FT                   /note="Glycoside hydrolase family 5"
FT                   /evidence="ECO:0000259|Pfam:PF00150"
SQ   SEQUENCE   431 AA;  48528 MW;  6A067CD1B64E2C7B CRC64;
     MRSLIPFFIV PLAVATALPA FQTVDLEKRS VNVGWPYGSD KIRGVNIGGW LVTEPFITPS
     LFEATGNNDI VDEWTFCQYQ DYDTAQAALK NHWDTWFTED DFAKISGAGL NHVRIPIGFW
     AYDVQGGEPY IQGQAEYLDR AIGWARNHNL AVIIDLHGAP GSQNGYDNSG RRGAADWATD
     EANVERTKNV IALLSTKYSD PQYYGVVTAL ALLNEPATYL NNQLLQTARQ YWYDAYGAAR
     YPFGNSDKSG LALVLHDGFQ PLSTFENYMT EPEYEDVLLD THNYQVFNDE YVAWNWDEHI
     SNICNKASTY SGSPLWLVVG EWTLATTDCA KYLNGRGIGS RYDGSYQGSS YVGSCDDKSN
     DVSRFSEEYK AFMHRFWEVQ TQVYEQNGQG WIHWTWKTES AADWSYEAGL DGGWIPWNAG
     SHDISLSSLC G
//