ID Q8NJG7_FUSCE Unreviewed; 492 AA.
AC Q8NJG7;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Trichothecene C-15 hydroxylase {ECO:0000313|EMBL:AAM48769.1};
GN Name=TRI11 {ECO:0000313|EMBL:AAM48769.1};
OS Fusarium cerealis (Fusarium crookwellense).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=56641 {ECO:0000313|EMBL:AAM48769.1};
RN [1] {ECO:0000313|EMBL:AAM48769.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 13721 {ECO:0000313|EMBL:AAM48769.1};
RX PubMed=12080147; DOI=10.1073/pnas.142307199;
RA Ward T.J., Bielawski J.P., Kistler H.C., Sullivan E., O'Donnell K.;
RT "Ancestral polymorphism and adaptive evolution in the trichothecene
RT mycotoxin gene cluster of phytopathogenic Fusarium.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:9278-9283(2002).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; AY102569; AAM48769.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8NJG7; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11058; CYP60B-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24305; CYTOCHROME P450; 1.
DR PANTHER; PTHR24305:SF230; CYTOCHROME P450 MONOOXYGENASE STHF; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|RuleBase:RU000461}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 492 AA; 55683 MW; 5D9CFECD8DA59C26 CRC64;
MFQYSPWPLL ALSGGTAVAY FVIMLVYNLF FHPLRNYPGP WLNTMTQIPH TLLMLCGLPH
KRHLALHMKY GPVVRIGPNM LSFNHPDAMK DVRGHRKSGE AEHGKDPIIV LSNGDNIVGS
DRENHTRFRR ALAYGFSAQA MLEQEPTFKA YVNQLFQRLH EQSSNGTKTV DISKWYTFTT
FDMIGDLAFG ESFGCLDNST YHPWVALAFE SLKSLAFMAE MGRYPRIAPY IGFLLPRGLL
NKFAENKELA SMKVRKRLDT ETDRPDFVGK ITQGLKAKGS SMEFNELASN ASVLIVAGSE
TTATLLSAAV YFLCSNPRTL ELLAEEVRST YTQADAIDLV STQGLRYMQA VLDEALRMYP
PVAGGGSPRK IAKGGSFVAG YFVPENTLVE NDMWAMHYDP KYFTQPHDFI PERWLGDARF
SSDRLDAVKP FSIGPRNCIG VNLAYAEMRM MLARTVWEFD IRLAESSRNW YQDSRVYLAW
NKPPLNVYLD PR
//
