ID SUCC_CORGL Reviewed; 398 AA.
AC Q8NMK7;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2002, sequence version 1.
DT 29-MAY-2013, entry version 80.
DE RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit beta;
DE EC=6.2.1.5;
DE AltName: Full=Succinyl-CoA synthetase subunit beta;
DE Short=SCS-beta;
GN Name=sucC; OrderedLocusNames=Cgl2566, cg2837;
OS Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 /
OS LMG 3730 / NCIMB 10025).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=196627;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RX PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA Ikeda M., Nakagawa S.;
RT "The Corynebacterium glutamicum genome: features and impacts on
RT biotechnological processes.";
RL Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RX PubMed=12948626; DOI=10.1016/S0168-1656(03)00154-8;
RA Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M.,
RA Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L.,
RA Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B.,
RA McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A.,
RA Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I.,
RA Tauch A.;
RT "The complete Corynebacterium glutamicum ATCC 13032 genome sequence
RT and its impact on the production of L-aspartate-derived amino acids
RT and vitamins.";
RL J. Biotechnol. 104:5-25(2003).
CC -!- CATALYTIC ACTIVITY: ATP + succinate + CoA = ADP + phosphate +
CC succinyl-CoA.
CC -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC similarity).
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC succinate from succinyl-CoA (ligase route): step 1/1.
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits (By
CC similarity).
CC -!- SIMILARITY: Belongs to the succinate/malate CoA ligase beta
CC subunit family.
CC -!- SIMILARITY: Contains 1 ATP-grasp domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAF21227.1; Type=Erroneous initiation;
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DR EMBL; BA000036; BAB99959.1; -; Genomic_DNA.
DR EMBL; BX927155; CAF21227.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_601764.2; NC_003450.3.
DR RefSeq; YP_226806.1; NC_006958.1.
DR ProteinModelPortal; Q8NMK7; -.
DR STRING; 196627.cg2837; -.
DR EnsemblBacteria; BAB99959; BAB99959; BAB99959.
DR EnsemblBacteria; CAF21227; CAF21227; cg2837.
DR GeneID; 1020512; -.
DR GeneID; 3345415; -.
DR KEGG; cgb:cg2837; -.
DR KEGG; cgl:NCgl2477; -.
DR PATRIC; 21497168; VBICorGlu203724_2500.
DR eggNOG; COG0045; -.
DR KO; K01903; -.
DR OMA; TQNKQFT; -.
DR ProtClustDB; PRK00696; -.
DR UniPathway; UPA00223; UER00999.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:HAMAP.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.30.470.20; -; 1.
DR Gene3D; 3.40.50.261; -; 1.
DR HAMAP; MF_00558; Succ_CoA_beta; 1; -.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013650; ATP-grasp_succ-CoA_synth-type.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR013816; ATP_grasp_subdomain_2.
DR InterPro; IPR005811; CoA_ligase.
DR InterPro; IPR017866; Succ-CoA_synthase_bsu_CS.
DR InterPro; IPR005809; Succ_CoA_synthase_bsu.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR11815; PTHR11815; 1.
DR Pfam; PF08442; ATP-grasp_2; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR PIRSF; PIRSF001554; SucCS_beta; 1.
DR SUPFAM; SSF52210; CoA_ligase; 1.
DR TIGRFAMs; TIGR01016; sucCoAbeta; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS01217; SUCCINYL_COA_LIG_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Ligase; Magnesium; Manganese;
KW Metal-binding; Nucleotide-binding; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1 398 Succinyl-CoA ligase [ADP-forming] subunit
FT beta.
FT /FTId=PRO_0000102829.
FT DOMAIN 9 237 ATP-grasp.
FT NP_BIND 35 100 ATP (By similarity).
FT METAL 189 189 Magnesium or manganese (By similarity).
FT METAL 191 191 Magnesium or manganese (By similarity).
SQ SEQUENCE 398 AA; 41764 MW; 6E0C127EC7DC5CEE CRC64;
MDLFEYQARD LFETHGVPVL KGIVASTPEA ARKAAEEIGG LTVVKAQVKV GGRGKAGGVR
VAPTSAQAFD AADAILGMDI KGHTVNQVMV AQGADIAEEY YFSILLDRAN RSYLAMCSVE
GGMEIEILAK EKPEALAKVE VDPLTGIDED KAREIVTAAG FETEVAEKVI PVLIKIWQVY
YEEEATLVEV NPLVLTDDGD VIALDGKITL DDNADFRHDN RGALAESAGG LDILELKAKK
NDLNYVKLDG SVGIIGNGAG LVMSTLDIVA AAGERHGGQR PANFLDIGGG ASAESMAAGL
DVILGDSQVR SVFVNVFGGI TACDVVAKGI VGALDVLGDQ ATKPLVVRLD GNNVVEGRRI
LAEYNHPLVT VVEGMDAAAD HAAHLANLAQ HGQFATAN
//
