ID   Q8QEA5_9HIV1            Unreviewed;       335 AA.
AC   Q8QEA5;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   22-FEB-2023, entry version 91.
DE   SubName: Full=Envelope glycoprotein {ECO:0000313|EMBL:AAL76854.1};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:AAL76854.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAL76854.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAL76854.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11752161; DOI=10.1128/JVI.76.2.707-716.2002;
RA   Zhu T., Muthui D., Holte S., Nickle D., Feng F., Brodie S., Hwangbo Y.,
RA   Mullins J.I., Corey L.;
RT   "Evidence for human immunodeficiency virus type 1 replication in vivo in
RT   CD14(+) monocytes and its potential role as a source of virus in patients
RT   on highly active antiretroviral therapy.";
RL   J. Virol. 76:707-716(2002).
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DR   EMBL; AF406244; AAL76854.1; -; Genomic_DNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   SUPFAM; SSF56502; gp120 core; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral envelope protein {ECO:0000313|EMBL:AAL76854.1};
KW   Virion {ECO:0000313|EMBL:AAL76854.1}.
FT   TRANSMEM        278..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..277
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   REGION          221..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAL76854.1"
FT   NON_TER         335
FT                   /evidence="ECO:0000313|EMBL:AAL76854.1"
SQ   SEQUENCE   335 AA;  37189 MW;  EC303A84D5DA90C3 CRC64;
     DGKGPCNNVS TVQCTHGIRP VVSTQLLLNG SLAEEEIVIR SENFTNNVKT IIVQLKKSVN
     ITCERPSNNT RKGVHMGPGK AWFTTQITGD IRKAYCNISR TEWNDTLKNI VTKLREHFKN
     KTIIFSPSSG GDPEIVTHSF NCGGEFFYCN TSQLFNSTWN NTWEGLNSTE VKNNTEGTIT
     LPCRIKQIIN MWQEVGKAMY APPIRGQIRC SSNITGLLLT RDGGNNTNGN NETFRPGGGD
     MRDNWRSELY KYKVVQIEPI GIAPTKAKRR VVRREKRAIG TIGAMFLGFL GAAGSTMGAA
     SLTLTVQARQ LLSGIVQQQN NLLRAIEAQQ HMLRL
//