ID   Q8QEN9_9HIV1            Unreviewed;       355 AA.
AC   Q8QEN9;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 2.
DT   22-FEB-2023, entry version 97.
DE   SubName: Full=Envelope glycoprotein {ECO:0000313|EMBL:AAL76720.2};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:AAL76720.2};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAL76720.2};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAL76720.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11752161; DOI=10.1128/JVI.76.2.707-716.2002;
RA   Zhu T., Muthui D., Holte S., Nickle D., Feng F., Brodie S., Hwangbo Y.,
RA   Mullins J.I., Corey L.;
RT   "Evidence for human immunodeficiency virus type 1 replication in vivo in
RT   CD14(+) monocytes and its potential role as a source of virus in patients
RT   on highly active antiretroviral therapy.";
RL   J. Virol. 76:707-716(2002).
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DR   EMBL; AF406050; AAL76720.2; -; Genomic_DNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   SUPFAM; SSF56502; gp120 core; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral envelope protein {ECO:0000313|EMBL:AAL76720.2};
KW   Virion {ECO:0000313|EMBL:AAL76720.2}.
FT   TRANSMEM        288..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..287
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAL76720.2"
FT   NON_TER         355
FT                   /evidence="ECO:0000313|EMBL:AAL76720.2"
SQ   SEQUENCE   355 AA;  38957 MW;  67860FDCAA0E8378 CRC64;
     GFAILKCNNK TFNGTGPCTN VSTVQCTHGI KPVVSTQLLL NGSLAEEEVV IRSENFTNNA
     KIIIVQLNES VEINCTRPNN NTRKGIHIGP GRAFYATGAI IGDIRQAHCN ISREKWNNTL
     RQIVEKLREQ FGKNKTIIFN QPSGGDPEIV MHSFNCGGEF FYCNTTPLFN STWSNNGSVT
     EGSNNNETII LPCRIKQIIN MWQEVGKAMY APPIRGQIRC SSNITGLLLT RDGGNNDTNG
     NETFRPGGGD MGDNWRSELY KYKVVKIEPL GVAPTKAKRR VVQREKRAAI GALFLGFLGA
     AGSTMGAASI TLTVQARLLL SGIVQQQNNL LKAIEAQQHL LQLTVWGIKQ LQARA
//