ID   Q8QEW0_9HIV1            Unreviewed;       302 AA.
AC   Q8QEW0;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   22-FEB-2023, entry version 94.
DE   SubName: Full=Envelope glycoprotein {ECO:0000313|EMBL:AAL76649.1};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:AAL76649.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAL76649.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAL76649.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11752161; DOI=10.1128/JVI.76.2.707-716.2002;
RA   Zhu T., Muthui D., Holte S., Nickle D., Feng F., Brodie S., Hwangbo Y.,
RA   Mullins J.I., Corey L.;
RT   "Evidence for human immunodeficiency virus type 1 replication in vivo in
RT   CD14(+) monocytes and its potential role as a source of virus in patients
RT   on highly active antiretroviral therapy.";
RL   J. Virol. 76:707-716(2002).
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DR   EMBL; AF405965; AAL76649.1; -; Genomic_DNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.210; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   SUPFAM; SSF56502; gp120 core; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral envelope protein {ECO:0000313|EMBL:AAL76649.1};
KW   Virion {ECO:0000313|EMBL:AAL76649.1}.
FT   TRANSMEM        248..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..247
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAL76649.1"
FT   NON_TER         302
FT                   /evidence="ECO:0000313|EMBL:AAL76649.1"
SQ   SEQUENCE   302 AA;  33362 MW;  4F87FE26446DA484 CRC64;
     LLLNGSLAEE EVVIRSENFT NNVKTIIVQL NESVQINCTR PNNNTRKSIH IGPGKAFYGT
     GDIIGDIRQA HCNLSVAKWN NTLKQIVTKL REQFGNKTIV FNQPSGGDPE IVMHTFNCGG
     EFFYCNTTQL FNSTWDWNDT AGLNSTGENI TLPCRIKQLV NMWQEVGKAM YAPPIRGPIR
     CSSNITGLLL TRDGGNTTNE TEVFRPGGGD MRDNWRSELY KYKVVKIEPI GVAPTRAKRR
     VVQREKRAVG LGAVFLGFLG AAGSTMGAAS VTLTVQARQL LSGIVQQQNN LLRAIEAQQH
     LL
//